The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility

被引：14
作者：
Zhou, Guannan [1 ,2 ]
Gu, Yuanyuan [1 ,3 ]
Zhou, Fangyue [1 ,2 ]
Zhang, Menglei [1 ,2 ]
Zhang, Ganrong [1 ,2 ]
Wu, Ligang [4 ]
Hua, Keqin [1 ,2 ]
Ding, Jingxin [1 ,2 ]
机构：
[1] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China
[2] Dept Gynecol, Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China
[3] East China Normal Univ, Changning Matern & Infant Hlth Hosp, Shanghai, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
extracellular vesicles; female infertility; male infertility; IVF; therapeutics; POLYCYSTIC-OVARY-SYNDROME; FOLLICULAR-FLUID; SEMINAL PLASMA; STROMAL CELLS; EXOSOMES; MICRORNAS; ENDOMETRIOSIS; FERTILIZATION; COMMUNICATION; INSUFFICIENCY;
D O I：
10.3389/fendo.2021.758206
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Infertility is becoming much more common and affects more couples. The past years witnessed the rapid development of the diagnosis and treatment upon infertility, which give numerous coupled more opportunities become parents. Extracellular vesicles are known as nano-sized membrane vesicles to play a major role in intracellular communication. In recent years, several basic and clinical studies have tried to investigate the correlation between the reproductive health/disorder and extracellular vesicles. However, the mechanism is still unclear. In this review, we reviewed the relationship between reproductive physiology and extracellular vesicles, and then collectively focused on the recent findings on the relationship between extracellular and infertility, and its consequent influence on the novel insight regarding the therapeutic strategies for infertility in the future clinical practice.
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页数：8
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