A new approach to asymmetric synthesis of β-amino alcohols by means of α-chirally protected amino alkyllithiums

被引：0

作者：

Tomoyasu, T

Tomooka, K

Nakai, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem Technol, Meguro Ku, Tokyo 152, Japan

[2] Otsuka Pharmaceut Factory Inc, Inst Nutr Res, Naruto, Tokushima 772, Japan

来源：

SYNLETT | 1998年 / 10期

关键词：

chiral alpha-amino alkyllithium; asymmetric synthesis; beta-amino alcohol; alpha-amino ketone;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, general synthetic approach to enantiopure alpha-amino ketones and syn-beta-amino alcohols is described which employs the doubly chiral N-protected alpha-amino alkyllithiums generated via Pearson's transmetalative protocol as the key synthetic intermediates.

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收藏

页码：1147 / +

页数：4

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