Acute infusion reactions induced by monoclonal antibody therapy

被引：28
作者：
Maggi, Enrico [1 ]
Vultaggio, Alessandra [2 ]
Matucci, Andrea [2 ]
机构：
[1] Univ Florence, Ctr Res Transfer & High Educ DENOTHE, Policlin Careggi, I-50134 Florence, Italy
[2] Policlin Careggi, Dept Biomed, Immunoallergol Unit, Florence, Italy
来源：
EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2011年 / 7卷 / 01期
关键词：
anaphylaxis; anti-TNF-alpha antibody; biological agents; drug allergy; infliximab; mAbs; monoclonal antibodies; SEVERE ANAPHYLACTIC REACTION; CETUXIMAB PLUS IRINOTECAN; CROHNS-DISEASE; RHEUMATOID-ARTHRITIS; MAINTENANCE THERAPY; INFLIXIMAB THERAPY; EPISODIC TREATMENT; CLINICAL-RESPONSE; PHASE-III; SAFETY;
D O I：
10.1586/ECI.10.90
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This article reports recent evidence on epidemiological data concerning monoclonal antibody (mAb) infusion-related anaphylaxis, as well as recent data on the correlation between mAb immunogenicity and safety profiles. Pathogenic mechanisms of mAb-related adverse reactions including hypersensitivity, IgE- and non-IgE-mediated events and cytokine release syndrome are also highlighted. Finally, the role of serum anti-mAb antibodies as markers to monitor the safety of such therapeutical compounds are extensively evaluated. The anaphylaxis occurring during therapy with the anti-TNF-alpha mAb infliximab, largely used in immune-mediated diseases, has been taken as a paradigm.
引用
收藏
页码：55 / 63
页数：9
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