Intranasal dexmedetomidine is an effective sedative agent for electroencephalography in children

被引:16
作者
Chen, Hang [1 ]
Yang, Fei [1 ]
Ye, Mao [1 ]
Liu, Hui [1 ]
Zhang, Jing [1 ]
Tian, Qin [1 ]
Liu, Ruiqi [1 ]
Yu, Qing [1 ]
Li, Shangyingying [1 ]
Tu, Shengfen [1 ]
机构
[1] Chongqing Med Univ, Childrens Hosp, Dept Anesthesiol, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China
关键词
Children; Electroencephalography; Intranasal dexmedetomidine; Sedation; PREMEDICATION; MIDAZOLAM; MRI;
D O I
10.1186/s12871-020-00978-z
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background Intranasal dexmedetomidine (DEX), as a novel sedation method, has been used in many clinical examinations of infants and children. However, the safety and efficacy of this method for electroencephalography (EEG) in children is limited. In this study, we performed a large-scale clinical case analysis of patients who received this sedation method. The purpose of this study was to evaluate the safety and efficacy of intranasal DEX for sedation in children during EEG. Methods This was a retrospective study. The inclusion criteria were children who underwent EEG from October 2016 to October 2018 at the Children's Hospital affiliated with Chongqing Medical University. All the children received 2.5 mu g center dot kg(- 1) of intranasal DEX for sedation during the procedure. We used the Modified Observer Assessment of Alertness/Sedation Scale (MOAA/S) and the Modified Aldrete score (MAS) to evaluate the effects of the treatment on sedation and resuscitation. The sex, age, weight, American Society of Anesthesiologists physical status (ASAPS), vital signs, sedation onset and recovery times, sedation success rate, and adverse patient events were recorded. Results A total of 3475 cases were collected and analysed in this study. The success rate of the initial dose was 87.0% (3024/3475 cases), and the success rate of intranasal sedation rescue was 60.8% (274/451 cases). The median sedation onset time was 19 mins (IQR: 17-22 min), and the sedation recovery time was 41 mins (IQR: 36-47 min). The total incidence of adverse events was 0.95% (33/3475 cases), and no serious adverse events occurred. Conclusions Intranasal DEX (2.5 mu g center dot kg(- 1)) can be safely and effectively used for EEG sedation in children.
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页数:5
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共 27 条
[1]   Ketamine: differential neurophysiological dynamics in functional networks in the rat brain [J].
Ahnaou, A. ;
Huysmans, H. ;
Biermans, R. ;
Manyakov, N. V. ;
Drinkenburg, W. H. I. M. .
TRANSLATIONAL PSYCHIATRY, 2017, 7 :e1237-e1237
[2]   Intranasal dexmedetomidine: an effective sedative agent for electroencephalogram and auditory brain response testing [J].
Baier, Nicole M. ;
Mendez, Suzanne S. ;
Kimm, Danielle ;
Velazquez, Amanda E. ;
Schroeder, Alan R. .
PEDIATRIC ANESTHESIA, 2016, 26 (03) :280-285
[3]   Options and Considerations for Procedural Sedation in Pediatric Imaging [J].
Berkenbosch, John W. .
PEDIATRIC DRUGS, 2015, 17 (05) :385-399
[4]   Intranasal dexmedetomidine, as midazolam-sparing drug, for MRI in preterm neonates [J].
Bua, Jenny ;
Massaro, Marta ;
Cossovel, Francesca ;
Monasta, Lorenzo ;
Brovedani, Pierpaolo ;
Cozzi, Giorgio ;
Barbi, Egidio ;
Demarini, Sergio ;
Travan, Laura .
PEDIATRIC ANESTHESIA, 2018, 28 (08) :747-748
[5]   Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model [J].
Charlton, Stuart T. ;
Whetstone, Joanne ;
Fayinka, Susan T. ;
Read, Kevin D. ;
Illum, Lisbeth ;
Davis, Stanley S. .
PHARMACEUTICAL RESEARCH, 2008, 25 (07) :1531-1543
[6]   Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease [J].
Chrysostomou, Constantinos ;
Komarlu, Rukmini ;
Lichtenstein, Steven ;
Shiderly, Dana ;
Arora, Gaurav ;
Orr, Richard ;
Wearden, Peter D. ;
Morell, Victor O. ;
Munoz, Ricardo ;
Jooste, Edmund H. .
INTENSIVE CARE MEDICINE, 2010, 36 (05) :836-842
[7]  
Clark Mathew, 2016, Anesth Essays Res, V10, P607
[8]   Electroencephalographic (EEG) density spectral array monitoring in children during sevoflurane anaesthesia: a prospective observational study [J].
de Heer, I. J. ;
Bouman, S. J. M. ;
Weber, F. .
ANAESTHESIA, 2019, 74 (01) :45-50
[9]   Influence of propofol on the electroencephalogram default mode network in patients of advanced age [J].
Ke, Jing-Dong ;
Xu, Min ;
Wang, Pei-Pei ;
Wang, Min ;
Tian, Ming ;
Chen, Andrew C. N. .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2018, 46 (11) :4660-4668
[10]   The effect of fasting practice on sedation with chloral hydrate [J].
Keidan, I ;
Gozal, D ;
Minuskin, T ;
Weinberg, M ;
Barkaly, H ;
Augarten, A .
PEDIATRIC EMERGENCY CARE, 2004, 20 (12) :805-807