Bedside and laboratory neuromonitoring in neonatal encephalopathy

被引：21
作者：
Chalak, L. [1 ]
Hellstrom-Westas, L. [2 ]
Bonifacio, S. [3 ]
Tsuchida, T. [4 ]
Chock, V [3 ]
El-Dib, M. [5 ]
Massaro, An N. [6 ,7 ]
Garcia-Alix, A. [8 ,9 ,10 ,11 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA
[2] Uppsala Univ, Uppsala Univ Hosp, Dept Womens & Childrens Hlth, Div Neonatol, Uppsala, Sweden
[3] Stanford Univ, Sch Med, Dept Pediat, Div Neonatal & Dev Med, 750 Welch Rd,Suite 315, Palo Alto, CA 94304 USA
[4] George Washington Univ, Childrens Natl Hosp, Sch Med & Hlth Sci, Dept Neurol & Pediat,Div Neurophysiol Epilepsy &, 111 Michigan Ave NW,West Wing,4th Floor, Washington, DC 20010 USA
[5] Harvard Med Sch, Brigham & Womens Hosp, Dept Pediat Newborn Med, 75 Francis St,CWN 418, Boston, MA 02115 USA
[6] George Washington Univ, Sch Med, Dept Pediat, Washington, DC USA
[7] Childrens Natl Hosp, Div Neonatol, Washington, DC USA
[8] Hosp St Joan Deu, Inst Recerca St Joan Deu, Barcelona, Spain
[9] Univ Barcelona, Barcelona, Spain
[10] NeNe Fdn, Madrid, Spain
[11] Passeig St Joan Deu 2, Barcelona 08950, Spain
[12] Newborn Brain Soc, POB 200783, Roxbury Crossing, MA 02120 USA
来源：
SEMINARS IN FETAL & NEONATAL MEDICINE | 2021年 / 26卷 / 05期
关键词：
HYPOXIC-ISCHEMIC ENCEPHALOPATHY; NEAR-INFRARED SPECTROSCOPY; AMPLITUDE-INTEGRATED EEG; CEREBRAL OXYGEN-SATURATION; NEURON-SPECIFIC ENOLASE; BRAIN-SPECIFIC PROTEINS; FULL-TERM; CEREBROVASCULAR AUTOREGULATION; THERAPEUTIC HYPOTHERMIA; PROGNOSTIC VALUE;
D O I：
10.1016/j.siny.2021.101273
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Several bedside and laboratory neuromonitoring tools are currently used in neonatal encephalopathy (NE) to assess 1) brain function [amplitude-integrated electroencephalogram (aEEG) and EEG], 2) cerebral oxygenation delivery and consumption [near-infrared spectroscopy (NIRS)] and 3) blood and cerebrospinal fluid biomarkers. The aim of the review is to provide the role of neuromonitoring in understanding the development of brain injury in these newborns and better predict their long-term outcome. Simultaneous use of these monitoring modalities may improve our ability to provide meaningful prognostic information regarding ongoing treatments. Evidence will be summarized in this review for each of these modalities, by describing (1) the methods, (2) the clinical evidence in context of NE both before and with hypothermia, and (3) the research and future directions.
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页数：9
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