Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics

被引：189
作者：
Smith, Lucas R. [1 ]
Cho, Sangkyun [1 ]
Discher, Dennis E. [1 ]
机构：
[1] Univ Penn, Mol & Cell Biophys Lab, Phys Sci Oncol Ctr, Philadelphia, PA 19104 USA
来源：
PHYSIOLOGY | 2018年 / 33卷 / 01期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; ATOMIC-FORCE MICROSCOPY; HEPATIC STELLATE CELLS; LAMIN-B RECEPTOR; SKELETAL-MUSCLE; FOCAL ADHESIONS; IN-VIVO; PULMONARY-FIBROSIS; MYOSIN EXPRESSION; STIFFNESS;
D O I：
10.1152/physiol.00026.2017
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.
引用
收藏
页码：16 / 25
页数：10
相关论文
共 50 条
  • [41] Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition
    Lee, Junmin
    Abdeen, Amr A.
    Zhang, Douglas
    Kilian, Kristopher A.
    [J]. BIOMATERIALS, 2013, 34 (33) : 8140 - 8148
  • [42] Cell-secreted extracellular matrix formation and differentiation of adipose-derived stem cells in 3D alginate scaffolds with tunable properties
    Guneta, Vipra
    Loh, Qiu Li
    Choong, Cleo
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2016, 104 (05) : 1090 - 1101
  • [43] Skeletal Extracellular Matrix Supports Cardiac Differentiation of Embryonic Stem Cells: a Potential Scaffold for Engineered Cardiac Tissue
    Hong, Xian
    Yuan, Yin
    Sun, Xiaoxi
    Zhou, Meiling
    Guo, Guangyu
    Zhang, Quan
    Hescheler, Juergen
    Xi, Jiaoya
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 45 (01) : 319 - 331
  • [44] Union is strength: matrix elasticity and microenvironmental factors codetermine stem cell differentiation fate
    Lv, Hongwei
    Li, Lisha
    Zhang, Yin
    Chen, Zhishen
    Sun, Meiyu
    Xu, Tiankai
    Tian, Licheng
    Lu, Man
    Ren, Min
    Liu, Yuanyuan
    Li, Yulin
    [J]. CELL AND TISSUE RESEARCH, 2015, 361 (03) : 657 - 668
  • [45] Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction
    Chi, Ani
    Yang, Chao
    Liu, Jie
    Zhai, Zhichen
    Shi, Xuetao
    [J]. ADVANCED SCIENCE, 2025, 12 (02)
  • [46] Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix
    Kim, In Gul
    Gil, Chang-Hyun
    Seo, Joseph
    Park, Soon-Jung
    Subbiah, Ramesh
    Jung, Taek-Hee
    Kim, Jong Soo
    Jeong, Young-Hoon
    Chung, Hyung-Min
    Lee, Jong Ho
    Lee, Man Ryul
    Moon, Sung-Hwan
    Park, Kwideok
    [J]. BIOMATERIALS, 2018, 150 : 100 - 111
  • [47] Cell-extracellular matrix dynamics
    Doyle, Andrew D.
    Nazari, Shayan S.
    Yamada, Kenneth M.
    [J]. PHYSICAL BIOLOGY, 2022, 19 (02)
  • [48] Embryonic-Like Mineralized Extracellular Matrix/Stem Cell Microspheroids as a Bone Graft Substitute
    Fu, Cuicui
    Luo, Dan
    Yu, Min
    Jiang, Nan
    Liu, Dawei
    He, Danqing
    Fu, Yu
    Zhang, Ting
    Qiao, Yiqiang
    Zhou, Yanheng
    Liu, Yan
    [J]. ADVANCED HEALTHCARE MATERIALS, 2018, 7 (19)
  • [49] Extracellular matrix type modulates mechanotransduction of stem cells
    Stanton, Alice E.
    Tong, Xinming
    Yang, Fan
    [J]. ACTA BIOMATERIALIA, 2019, 96 : 310 - 320
  • [50] Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles
    Meyer, Gretchen A.
    Lieber, Richard L.
    [J]. JOURNAL OF BIOMECHANICS, 2011, 44 (04) : 771 - 773
12345