Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics

被引：187
|
作者：
Smith, Lucas R. [1 ]
Cho, Sangkyun [1 ]
Discher, Dennis E. [1 ]
机构：
[1] Univ Penn, Mol & Cell Biophys Lab, Phys Sci Oncol Ctr, Philadelphia, PA 19104 USA
来源：
PHYSIOLOGY | 2018年 / 33卷 / 01期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; ATOMIC-FORCE MICROSCOPY; HEPATIC STELLATE CELLS; LAMIN-B RECEPTOR; SKELETAL-MUSCLE; FOCAL ADHESIONS; IN-VIVO; PULMONARY-FIBROSIS; MYOSIN EXPRESSION; STIFFNESS;
D O I：
10.1152/physiol.00026.2017
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.
引用
收藏
页码：16 / 25
页数：10
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