Telomeres and essential hypertension

被引：14
作者：
Aviv, A
Aviv, H
机构：
[1] Univ Med & Dent New Jersey, Hypertens Res Ctr, New Jersey Med Sch, Newark, NJ 07103 USA
[2] Univ Med & Dent New Jersey, Ctr Human & Mol Genet, New Jersey Med Sch, Newark, NJ 07103 USA
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1999年 / 12卷 / 04期
关键词：
genetics; genetic linkage; phenotype; complex trait; aneuploidy; telomere attrition; essential hypertension;
D O I：
10.1016/S0895-7061(98)00202-7
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The dynamics of telomere attrition in human beings might shape the course of age-dependent, complex genetic traits. One of these traits is essential hypertension. Age-dependent telomere attrition could lead to critically shortened telomeres and aneuploidy (ie, the loss or gain of chromosomes) with a resultant mosaicism that will be variably expressed in different cells and tissues. The chromosomal instability and loss of heterozygosity resulting from this process would promote an age-dependent expression of variant genes that harbor susceptibility for essential hypertension or genes that accelerate the process of aging. (C) 1999 American Journal of Hypertension, Ltd.
引用
收藏
页码：427 / 432
页数：6
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