Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus

被引:56
作者
Tavakoli, Javad [1 ,2 ]
Diwan, Ashish D. [1 ,2 ,3 ]
Tipper, Joanne L. [1 ]
机构
[1] Univ Technol Sydney, Fac Engn & Informat Technol, Ctr Hlth Technol, Sch Biomed Engn, Ultimo 2007, Australia
[2] Univ New South Wales, SpineLabs, St George & Sutherland Clin Sch, Sydney, NSW 2052, Australia
[3] St George Hosp Campus, Dept Orthopaed Surg, Spine Serv, Kogarah, NSW 2217, Australia
关键词
intervertebral disc; annulus fibrosus; repair; regeneration; herniation; cell-therapy; gene-therapy; biomolecule-therapy; MESENCHYMAL STEM-CELLS; INTRADISCAL PULSED RADIOFREQUENCY; INTER-LAMELLAR MATRIX; INTERVERTEBRAL DISC; IN-VITRO; DEGENERATED DISC; ELASTIC FIBERS; BIODEGRADABLE HYDROGELS; NUCLEUS PULPOSUS; ANULUS FIBROSUS;
D O I
10.3390/ijms21144889
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have failed so far and no effective strategy has translated into a successful clinical outcome. Of particular significance, the failure of strategies to repair the AF has been a major drawback in the regeneration of IVD and nucleus replacement. It is unlikely to secure regenerative mediators (cells, genes, and biomolecules) and artificial nucleus materials after injection with an unsealed AF, as IVD is exposed to significant load and large deformation during daily activities. The AF defects strongly change the mechanical properties of the IVD and activate catabolic routes that are responsible for accelerating IVD degeneration. Therefore, there is a strong need to develop effective therapeutic strategies to prevent or reconstruct AF damage to support operational IVD regenerative strategies and nucleus replacement. By the way of this review, repair and regenerative strategies for AF reconstruction, their current status, challenges ahead, and future outlooks were discussed.
引用
收藏
页码:1 / 20
页数:19
相关论文
共 157 条
[1]   Effect of anular repair on the healing strength of the intervertebral disc - A sheep model [J].
Ahlgren, BD ;
Lui, W ;
Herkowitz, HN ;
Panjabi, MM ;
Guiboux, JP .
SPINE, 2000, 25 (17) :2165-2170
[2]   NF-B-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease [J].
Ahmed, Aisha S. ;
Berg, Svante ;
Alkass, Kanar ;
Druid, Henrik ;
Hart, David A. ;
Svensson, Camilla I. ;
Kosek, Eva .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (03)
[3]   The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix [J].
Alini, M ;
Li, W ;
Markovic, P ;
Aebi, M ;
Spiro, RC ;
Roughley, PJ .
SPINE, 2003, 28 (05) :446-453
[4]   MicroRNA 17-92 expressed by a transposone-based vector changes expression level of cell-cycle-related genes [J].
Attar, Marzieh ;
Arefian, Ehsan ;
Nabiuni, Mohammad ;
Adegani, Fatemeh Jamshidi ;
Bakhtiari, Seyed Hamid Aghaee ;
Karimi, Zahra ;
Barzegar, Mansoureh ;
Soleimani, Masoud .
CELL BIOLOGY INTERNATIONAL, 2012, 36 (11) :1005-1012
[5]   Prospective, Multicenter, Randomized, Controlled Study of Anular Repair in Lumbar Discectomy Two-Year Follow-up [J].
Bailey, Alexander ;
Araghi, Ali ;
Blumenthal, Scott ;
Huffmon, George V. .
SPINE, 2013, 38 (14) :1161-1169
[6]   Closure of the annulus fibrosus of the intervertebral disc using a novel suture application device-in vivo porcine and ex vivo biomechanical evaluation [J].
Bateman, Antony H. ;
Balkovec, Christian ;
Akens, Margarete K. ;
Chan, Andrea H. W. ;
Harrison, Robert D. ;
Oakden, Wendy ;
Yee, Albert J. M. ;
McGill, Stuart M. .
SPINE JOURNAL, 2016, 16 (07) :889-895
[7]   Biological challenges for regeneration of the degenerated disc using cellular therapies [J].
Bendtsen, Michael ;
Bunger, Cody ;
Colombier, Pauline ;
Le Visage, Catherine ;
Roberts, Sally ;
Sakai, Daisuke ;
Urban, Jill P. G. .
ACTA ORTHOPAEDICA, 2016, 87 :39-46
[8]  
Benneker L M, 2014, Eur Cell Mater, V27, P5
[9]   Metabolism of the intervertebral disc: Effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells [J].
Bibby, SRS ;
Jones, DA ;
Ripley, RM ;
Urban, JPG .
SPINE, 2005, 30 (05) :487-496
[10]  
Borde B, 2014, J BIOMED MAT RES A