A Nationwide Population-Based Cohort Study: Will Anxiety Disorders Increase Subsequent Cancer Risk?

被引：17

作者：

Liang, Ji-An ^{[1
,2
,3
]}

Sun, Li-Min ^{[4
]}

Su, Kuan-Pin ^{[2
,3
,5
,6
]}

Chang, Shih-Ni ^{[7
,8
,9
,10
]}

Sung, Fung-Chang ^{[7
,8
]}

Muo, Chih-Hsin ^{[7
,8
]}

Kao, Chia-Hung ^{[2
,3
,11
,12
]}

机构：

[1] China Med Univ Hosp, Dept Radiat Oncol, Taichung, Taiwan

[2] China Med Univ, Inst Clin Med Sci, Coll Med, Taichung, Taiwan

[3] China Med Univ, Sch Med, Coll Med, Taichung, Taiwan

[4] Zuoying Armed Forces Gen Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan

[5] China Med Univ Hosp, Dept Gen Psychiat, Taichung, Taiwan

[6] China Med Univ Hosp, Mind Body Interface Lab, Taichung, Taiwan

[7] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[8] China Med Univ, Inst Environm Hlth, Coll Publ Hlth, Taichung, Taiwan

[9] China Med Univ, PhD Program Canc Biol & Drug Discovery, Taichung, Taiwan

[10] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[11] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[12] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

来源：

PLOS ONE | 2012年 / 7卷 / 04期

关键词：

BREAST-CANCER; PSYCHOSOCIAL FACTORS; LIFE EVENTS; STRESS; DEPRESSION; METAANALYSIS; OUTPATIENTS; PREVALENCE; NONSMOKERS; SMOKERS;

D O I：

10.1371/journal.pone.0036370

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: The aim of this study was to evaluate a possible association between malignancy and anxiety disorders (AD) in Taiwan. Methods: We employed data from the National Health Insurance system of Taiwan. The AD cohort contained 24,066 patients with each patient randomly frequency matched according to age and sex with 4 individuals from the general population without AD. Cox's proportional hazard regression analysis was conducted to estimate the influence of AD on the risk of cancer. Results: Among patients with AD, the overall risk of developing cancer was only 1% higher than among subjects without AD, and the difference was not significant (hazard ratio [HR] = 1.01, 95% confidence interval [ 95% CI] = 0.95-1.07). With regard to individual types of cancer, the risk of developing prostate cancer among male patients with AD was significantly higher (HR = 1.32, 95% CI = 1.02-1.71). On the other hand, the risk of cervical cancer among female patients with AD was marginally significantly lower than among female subjects without AD (HR = 0.72, 95% CI = 0.51-1.03). Limitations: One major limitation is the lack of information regarding the life style or behavior of patients in the NHI database, such as smoking and alcohol consumption. Conclusions: Despite the failure to identify a relationship between AD and the overall risk of cancer, we found that Taiwanese patients with AD had a higher risk of developing prostate cancer and a lower risk of developing cervical cancer.

引用

页数：6

共 32 条

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