Highly Regioselective Synthesis of 1,3-Diiodonaphthalene Derivatives via a Sequential Cascade Iodocyclization

被引：42

作者：

Wang, Li-Jing

Zhu, Hai-Tao

Lu, Lei

Yang, Fang

Liu, Xue-Yuan

Liang, Yong-Min ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 08期

基金：

美国国家科学基金会;

关键词：

MEDIATED ELECTROPHILIC CYCLIZATION; SUBSTITUTED QUINOLINES; EFFICIENT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; 5-ENDO-DIG CYCLIZATIONS; INDENE DERIVATIVES; BETA-IODOFURANS; ALPHA-PYRONES; ALKYNES; ISOQUINOLINES;

D O I：

10.1021/ol300457c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and flexible sequentially cascade iodocyclization for the synthesis of highly substituted 1,3-diiodinated naphthalene derivatives in up to 99% yield under mild conditions is reported. The dihalogenated moiety can be readily introduced into the naphthalenes in a position that is usually not easily functionalized.

引用

页码：1990 / 1993

页数：4

共 52 条

[51] Electrophilic cyclization of 4-thio-but-2-yn-1-ols via 1,2-migration of the thio group: efficient synthesis of 2,4-dihalo-3-thio-substituted furans [J].