Passive and Active Target Delivery of Drugs to Ischemic Myocardium

被引：8
|
作者：
Galagudza, M. M. [1 ,2 ]
Korolev, D. V. [1 ,2 ]
Sonin, D. L. [1 ,2 ]
Alexandrov, I. V. [1 ]
Minasian, S. M. [1 ,2 ]
Postnov, V. N. [1 ,3 ]
Kirpicheva, E. B. [1 ,3 ]
Papayan, G. V. [1 ,2 ]
Uskov, I. S. [1 ,2 ]
机构：
[1] VA Almazov Ctr Heart Blood & Endocrinol, St Petersburg, Russia
[2] IP Pavlov State Med Univ, St Petersburg, Russia
[3] St Petersburg State Univ, Fac Chem, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 152卷 / 01期
关键词：
target delivery; drugs; nanoparticles; myocardium;
D O I：
10.1007/s10517-011-1466-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.
引用
收藏
页码：105 / 107
页数：3
相关论文
共 50 条
  • [1] Passive and Active Target Delivery of Drugs to Ischemic Myocardium
    M. M. Galagudza
    D. V. Korolev
    D. L. Sonin
    I. V. Alexandrov
    S. M. Minasian
    V. N. Postnov
    E. B. Kirpicheva
    G. V. Papayan
    I. S. Uskov
    Bulletin of Experimental Biology and Medicine, 2011, 152 : 105 - 107
  • [2] Postsystolic shortening in ischemic myocardium - Active contraction or passive recoil?
    Skulstad, H
    Edvardsen, T
    Urheim, S
    Rabben, SI
    Stugaard, M
    Lyseggen, E
    Ihlen, H
    Smiseth, OA
    CIRCULATION, 2002, 106 (06) : 718 - 724
  • [3] OXYGEN DELIVERY TO THE ISCHEMIC MYOCARDIUM
    DIGERNESS, SB
    VANINI, V
    WIDEMAN, FE
    CIRCULATION, 1980, 62 (04) : 233 - 233
  • [4] Active and passive stresses in the myocardium
    Shoucri, RM
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 279 (05): : H2519 - H2528
  • [5] PRESERVATION EFFECTS OF DRUGS ON THE ISCHEMIC MYOCARDIUM
    YAMASAWA, I
    NAGAI, Y
    KIYOMI, S
    TAKAHASHI, H
    MINAMI, H
    AMARI, H
    KIMURA, K
    TAKANASHI, M
    KONNO, S
    YAOITA, N
    TSUBUCHI, K
    KANEKO, Y
    AKABA, N
    ABE, S
    KOBAYASHI, Y
    NOHARA, Y
    HACHIYA, T
    SASSA, H
    MURAYAMA, Y
    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1981, 45 (08): : 978 - 979
  • [6] PROTECTION OF THE ISCHEMIC MYOCARDIUM WITH CALCIUM ANTAGONISTIC DRUGS
    YAMASAWA, I
    NOHARA, Y
    KONNO, S
    NAGAI, Y
    YAOITA, N
    KANEKO, Y
    TAKAHASHI, H
    TAKANASHI, M
    ABE, T
    HACHIYA, T
    SASSA, H
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1983, 33-1 (03): : 389 - 396
  • [7] RADIOFREQUENCY ABLATION OF VENTRICULAR MYOCARDIUM USING ACTIVE FIXATION AND PASSIVE CONTACT CATHETER DELIVERY SYSTEMS
    AN, H
    SAKSENA, S
    JANSSEN, M
    OSYPKA, P
    AMERICAN HEART JOURNAL, 1989, 118 (01) : 69 - 77
  • [8] Apoptosis as a therapeutic target in acutely ischemic myocardium
    Garg, S
    Hofstra, L
    Reutelingsperger, C
    Narula, J
    CURRENT OPINION IN CARDIOLOGY, 2003, 18 (05) : 372 - 377
  • [9] Passive targeting of ischemic myocardium with the use of silica nanoparticles
    Galagudza M.M.
    Korolev D.V.
    Sonin D.L.
    Aleksandrov I.V.
    Postnov V.N.
    Papayan G.V.
    Shlyakhto E.V.
    Nanotechnologies in Russia, 2010, 5 (11): : 844 - 850
  • [10] IS STUNNED MYOCARDIUM DUE TO PASSIVE STRETCH OF THE ISCHEMIC REGION
    STAHL, L
    AVERSANO, T
    AMBROSIO, G
    BECKER, L
    CIRCULATION, 1986, 74 (04) : 494 - 494
12345