Passive and Active Target Delivery of Drugs to Ischemic Myocardium

被引：8

作者：

Galagudza, M. M. ^{[1
,2
]}

Korolev, D. V. ^{[1
,2
]}

Sonin, D. L. ^{[1
,2
]}

Alexandrov, I. V. ^{[1
]}

Minasian, S. M. ^{[1
,2
]}

Postnov, V. N. ^{[1
,3
]}

Kirpicheva, E. B. ^{[1
,3
]}

Papayan, G. V. ^{[1
,2
]}

Uskov, I. S. ^{[1
,2
]}

机构：

[1] VA Almazov Ctr Heart Blood & Endocrinol, St Petersburg, Russia

[2] IP Pavlov State Med Univ, St Petersburg, Russia

[3] St Petersburg State Univ, Fac Chem, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 152卷 / 01期

关键词：

target delivery; drugs; nanoparticles; myocardium;

D O I：

10.1007/s10517-011-1466-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.

引用

页码：105 / 107

页数：3

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