Regulation of Terminal Differentiation Programs in the Nervous System

被引：152
|
作者：
Hobert, Oliver [1 ,2 ]
机构：
[1] Columbia Univ, Howard Hughes Med Inst, Med Ctr, New York, NY 10032 USA
[2] Columbia Univ, Dept Biochem & Mol Biophys, Med Ctr, New York, NY 10032 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 | 2011年 / 27卷
关键词：
neuronal identity; transcriptional regulation; terminal selector; regulon; CAENORHABDITIS-ELEGANS; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; SELECTOR GENES; SPECIFICATION; NEURONS; NURR1; IDENTIFICATION; ARCHITECTURE; EVOLUTION;
D O I：
10.1146/annurev-cellbio-092910-154226
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The generation of individual neuron types in the nervous system is a multistep process whose endpoint is the expression of neuron type specific batteries of terminal differentiation genes that determine the functional properties of a neuron. This review focuses on the regulatory mechanisms that are involved in controlling the terminally differentiated state of a neuron. I review several case studies from invertebrate and vertebrate nervous systems that reveal that many terminal differentiation features of a neuron are coregulated via terminal selector transcription factors that initiate and maintain terminal differentiation programs.
引用
收藏
页码：681 / 696
页数：16
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