Role of N6-methyladenosine modification in cancer

被引：178

作者：

Deng, Xiaolan ^{[1
,2
,3
,4
]}

Su, Rui ^{[2
,3
,4
]}

Feng, Xuesong ^{[1
]}

Wei, Minjie ^{[1
]}

Chen, Jianjun ^{[2
,3
,4
]}

机构：

[1] China Med Univ, Sch Pharm, Shenyang 110122, Peoples R China

[2] City Hope Natl Med Ctr, Beckman Res Inst, Dept Syst Biol, Monrovia, CA 91016 USA

[3] City Hope Natl Med Ctr, Beckman Res Inst, Gehr Family Ctr Leukemia Res, Monrovia, CA 91016 USA

[4] Univ Cincinnati, Coll Med, Dept Canc Biol, Cincinnati, OH 45219 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2018年 / 48卷

基金：

美国国家卫生研究院;

关键词：

MESSENGER-RNA METHYLATION; ACUTE MYELOID-LEUKEMIA; GENE-EXPRESSION REGULATION; BODY-MASS INDEX; STEM-CELLS; FTO GENE; ADULT OBESITY; NUCLEAR-RNA; M(6)A; TRANSLATION;

D O I：

10.1016/j.gde.2017.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As the most abundant internal modification in eukaryotic messenger RNAs identified, N-6-methyladenosine (m(6)A) has been shown recently to play essential roles in various normal bioprocesses. Evidence is emerging that m(6)A modification and its regulatory proteins also play critical roles in various cancers including leukemia, brain tumor, breast cancer and lung cancer, etc. For instance, FTO, the first m(6)A demethylase identified, has been reported recently to play an oncogenic role in leukemia and glioblastoma. ALKBH5 (another m(6)A demethylase) has been reported to exert a tumor-promoting function in glioblastoma and breast cancer. METTL3 (a major m(6)A methyltransferase) likely plays distinct roles between glioblastoma and lung cancer. Here we discuss the recent progress and future prospects in study of m(6)A machinery in cancer.

引用

页码：1 / 7

页数：7

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