Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates

被引：17
作者：
Lewis, Brittany B. [1 ]
Carter, Rebecca A. [1 ]
Pamer, Eric G. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Immunol Programs, Sloan Kettering Inst, Infect Dis Serv,Dept Med, New York, NY 10065 USA
来源：
ANAEROBE | 2016年 / 41卷
基金：
美国国家卫生研究院;
关键词：
Clostridium difficile; Secondary bile acid; SPORE GERMINATION; DISEASE SEVERITY; INFECTION; EPIDEMIC; EMERGENCE; SALTS; RESISTANCE; EFFICIENCY; OUTBREAK; RIBOTYPE;
D O I：
10.1016/j.anaerobe.2016.05.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：32 / 36
页数：5
相关论文
共 40 条
  • [1] Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection
    Abt, Michael C.
    Lewis, Brittany B.
    Caballero, Silvia
    Xiong, Huizhong
    Carter, Rebecca A.
    Susac, Boze
    Ling, Lilan
    Leiner, Ingrid
    Pamer, Eric G.
    [J]. CELL HOST & MICROBE, 2015, 18 (01) : 27 - 37
  • [2] Historical perspectives on studies of Clostridium difficile and C difficile infection
    Bartlett, John G.
    [J]. CLINICAL INFECTIOUS DISEASES, 2008, 46 : S4 - S11
  • [3] Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    Buffie, Charlie G.
    Bucci, Vanni
    Stein, Richard R.
    McKenney, Peter T.
    Ling, Lilan
    Gobourne, Asia
    No, Daniel
    Liu, Hui
    Kinnebrew, Melissa
    Viale, Agnes
    Littmann, Eric
    van den Brink, Marcel R. M.
    Jenq, Robert R.
    Taur, Ying
    Sander, Chris
    Cross, Justin R.
    Toussaint, Nora C.
    Xavier, Joao B.
    Pamer, Eric G.
    [J]. NATURE, 2015, 517 (7533) : 205 - U207
  • [4] Profound Alterations of Intestinal Microbiota following a Single Dose of Clindamycin Results in Sustained Susceptibility to Clostridium difficile-Induced Colitis
    Buffie, Charlie G.
    Jarchum, Irene
    Equinda, Michele
    Lipuma, Lauren
    Gobourne, Asia
    Viale, Agnes
    Ubeda, Carles
    Xavier, Joao
    Pamer, Eric G.
    [J]. INFECTION AND IMMUNITY, 2012, 80 (01) : 62 - 73
  • [5] Variation in germination of Clostridium difficile clinical isolates correlates to disease severity
    Carlson, Paul E., Jr.
    Kaiser, Alyssa M.
    McColm, Sarah A.
    Bauer, Jessica M.
    Young, Vincent B.
    Aronoff, David M.
    Hanna, Philip C.
    [J]. ANAEROBE, 2015, 33 : 64 - 70
  • [6] HETEROGENEITY OF BILE-SALTS RESISTANCE IN THE LACTOBACILLUS ISOLATES OF A PROBIOTIC CONSORTIUM
    CHATEAU, N
    DESCHAMPS, AM
    SASSI, AH
    [J]. LETTERS IN APPLIED MICROBIOLOGY, 1994, 18 (01) : 42 - 44
  • [7] David Griffiths, 2010, J CLIN MICROBIOL, V48, P770
  • [8] Dineen Sean S., 2009, CURR PROTOC MICROB A, V9A-1, P4
  • [9] Emma Stevenson, 2015, TRENDS MICROBIOL, V23, P275
  • [10] The Evolution of Urban C. difficile Infection (CDI): CDI in 2009-2011 Is Less Severe and has Better Outcomes Than CDI in 2006-2008
    Feuerstadt, Paul
    Das, Rohit
    Brandt, Lawrence J.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (08) : 1265 - 1276
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