Folate-Conjugated Cell Membrane Mimetic Polymer Micelles for Tumor-Cell-Targeted Delivery of Doxorubicin

被引：28

作者：

Lu, Qjan ^{[1
]}

Yi, Meijun ^{[1
]}

Zhang, Mengchen ^{[1
]}

Shi, Zhangyu ^{[1
]}

Zhang, Shiping ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Natl Demonstrat Ctr Expt Chem Educ,Minist Educ, Xian 710127, Shaanxi, Peoples R China

来源：

LANGMUIR | 2019年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DRUG-DELIVERY; COPOLYMER MICELLES; PRODRUG MICELLES; IN-VITRO; NANOPARTICLES; PHOSPHORYLCHOLINE; PHAGOCYTOSIS; NANOCARRIERS; CARRIERS; RELEASE;

D O I：

10.1021/acs.langmuir.8b03693

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tumor-targeting nano-drug-delivery systems hold great potential to improve the therapeutic efficacy and alleviate the side effects of cancer treatments. Herein, folic acid (FA)-decorated amphiphilic copolymer of FA-P(MPC-co-MaPCL) (MPC: 2-methacryloxoethyl phosphorylcholine, MaPCL: poly(epsilon-caprolactone) macromonomer) is synthesized and its micelles are fabricated for doxorubicin (DOX) delivery. And non-FA-decorated P(MPC-co-MaPCL) micelles are used as the control. Dynamic light scattering and scanning electron microscopy measurements reveal that FA-P(MPC-co-MaPCL) and P(MPC-co-MaPCL) micelles are spherical with average diameters of 140 and 90 nm, respectively. The evaluation in vitro demonstrates that the blank micelles are nontoxic, while DOX-loaded FA-P(MPC-co-MaPCL) micelles show significant cytotoxicity to HeLa cells and slight cytotoxicity to L929 cells. Moreover, the cellular uptake of DOX-loaded FA-P(MPC-co-MaPCL) micelles in HeLa cells are 4.3 fold and 1.7-fold higher than that of DOX-loaded P(MPC-co-MaPCL) micelles and free DOX after 6 h of incubation, respectively. These results indicate the great potential of this system in anticancer target drug-delivery applications.

引用

页码：504 / 512

页数：9

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[11] Biomimetic drug nanocarriers prepared by miniemulsion polymerization for near-infrared imaging and photothermal therapy [J].