Metabotropic glutamate receptors and the control of chronic pain

被引：88

作者：

Chiechio, Santina ^{[1
]}

Nicoletti, Ferdinando ^{[2
,3
]}

机构：

[1] Univ Catania, Dept Drug Sci, I-95124 Catania, Italy

[2] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Rome, Italy

[3] INM Neuromed, Pozzilli, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 01期

关键词：

NAAG PEPTIDASE INHIBITORS; GROUP-II; INFLAMMATORY PAIN; N-ACETYLASPARTYLGLUTAMATE; NEUROPATHIC PAIN; DORSAL-HORN; SYNAPTIC-TRANSMISSION; CENTRAL SENSITIZATION; ANALGESIC ACTIVITY; AMYGDALA NEURONS;

D O I：

10.1016/j.coph.2011.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past two decades metabotropic glutamate (mGlu) receptor ligands have been investigated for their potential therapeutic effects in different disorders of the central nervous system (CNS), including anxiety, depression, schizophrenia, and neurodegenerative diseases. In addition, it has been widely demonstrated that mGlu receptors are able to modulate pain transmission both in inflammatory and neuropathic pain models. A large number of preclinical studies combining the use of selective ligands with the knockout strategy have revealed more details about the role of the different mGlu receptor subtypes in the modulation of pain information. This review will address the role of mGlu receptors in pain sensitivity focusing on different strategies to achieve pain control by targeting specific mGlu receptor subtypes. Specifically, pharmacological interventions aimed at inhibiting group I mGlu receptor-mediated signaling and/or potentiating groups II and Ill mGlu receptor signaling together with an epigenetic approach leading to an increased expression of mGlu2 receptors will be discussed.

引用

页码：28 / 34

页数：7

共 87 条

[1] Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model [J].

Adedoyin, Mary O. ;

Vicini, Stefano ;

Neale, Joseph H. .

MOLECULAR PAIN, 2010, 6

[2]

[Anonymous], 2009, MOL PHARM, V75, P1014

[3]

[Anonymous], 2006, MOL PAIN, V2, P20

[4] Peripheral group I metabotropic glutamate receptors modulate nociception in mice [J].

Bhave, G ;

Karim, F ;

Carlton, SM ;

Gereau, RW .

NATURE NEUROSCIENCE, 2001, 4 (04) :417-423

[5] Neuropharmacology of AMPA and kainate receptors [J].

Bleakman, D ;

Lodge, D .

NEUROPHARMACOLOGY, 1998, 37 (10-11) :1187-1204

[6] Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn [J].

Boyce, S ;

Wyatt, A ;

Webb, JK ;

O'Donnell, R ;

Mason, G ;

Rigby, M ;

Sirinathsinghji, D ;

Hill, RG ;

Rupniak, NMJ .

NEUROPHARMACOLOGY, 1999, 38 (05) :611-623

[7] CLONING AND CHARACTERIZATION OF AN EXTRACELLULAR CA2+-SENSING RECEPTOR FROM BOVINE PARATHYROID [J].

BROWN, EM ;

GAMBA, G ;

RICCARDI, D ;

LOMBARDI, M ;

BUTTERS, R ;

KIFOR, O ;

SUN, A ;

HEDIGER, MA ;

LYTTON, J ;

HEBERT, SC .

NATURE, 1993, 366 (6455) :575-580

[8] The extracellular calcium-sensing receptor: Its role in health and disease [J].

Brown, EM ;

Pollak, M ;

Hebert, SC .

ANNUAL REVIEW OF MEDICINE, 1998, 49 :15-29

[9] Metabotropic Glutamate Receptor 5 Activation Inhibits Microglial Associated Inflammation and Neurotoxicity [J].

Byrnes, Kimberly R. ;

Stoica, Bogdan ;

Loane, David J. ;

Riccio, Angela ;

Davis, Margaret I. ;

Faden, Alan I. .

GLIA, 2009, 57 (05) :550-560

[10] Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells [J].

Cabello, Nuria ;

Gandia, Jorge ;

Bertarelli, Daniela C. G. ;

Watanabe, Masahiko ;

Lluis, Carme ;

Franco, Rafael ;

Ferre, Sergi ;

Lujan, Rafael ;

Ciruela, Francisco .

JOURNAL OF NEUROCHEMISTRY, 2009, 109 (05) :1497-1507

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