Combined Amino Acid Positron Emission Tomography and Advanced Magnetic Resonance Imaging in Glioma Patients

被引：45

作者：

Lohmann, Philipp ^{[1
]}

Werner, Jan-Michael ^{[2
,3
]}

Shah, N. Jon ^{[1
,4
,5
]}

Fink, Gereon R. ^{[1
,2
,3
]}

Langen, Karl-Josef ^{[1
,6
]}

Galldiks, Norbert ^{[1
,2
,3
,7
,8
]}

机构：

[1] Forschungszentrum Juelich, Inst Neurosci & Med INM 3 4 5 11, D-52425 Julich, Germany

[2] Univ Cologne, Fac Med, Dept Neurol, D-50937 Cologne, Germany

[3] Univ Cologne, Univ Hosp Cologne, D-50937 Cologne, Germany

[4] JARA BRAIN Translat Med, D-52074 Aachen, Germany

[5] Rhein Westfal TH Aachen, Dept Neurol, D-52074 Aachen, Germany

[6] Rhein Westfal TH Aachen, Dept Nucl Med, D-52074 Aachen, Germany

[7] Univ Cologne, CIO, D-50937 Cologne, Germany

[8] Univ Bonn, D-50937 Cologne, Germany

来源：

CANCERS | 2019年 / 11卷 / 02期

关键词：

C-11]-methyl-L-methionine (MET); O-(2-[F-18]-fluoroethyl)-L-tyrosine (FET); 3,4-dihydroxy-6-[F-18]-fluoro-L-phenylalanine (FDOPA); magnetic resonance spectroscopy; perfusion-weighted imaging; diffusion-weighted imaging; chemical exchange saturation transfer; brain tumors; high-grade glioma; hybrid PET; MRI scanner; DIFFUSION-WEIGHTED MRI; HIGH-GRADE GLIOMAS; BRAIN-TUMOR; IN-VIVO; C-11-METHIONINE PET; SPATIAL CORRELATION; RADIATION NECROSIS; CEREBRAL GLIOMAS; CONVENTIONAL MRI; F-18-FET PET;

D O I：

10.3390/cancers11020153

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) provide valuable information about brain tumor patients. Particularly amino acid PET, advanced MRI techniques, and combinations thereof are of great interest for the non-invasive assessment of biological characteristics in patients with primary or secondary brain cancer. A methodological innovation that potentially advances research in patients with brain tumors is the increasing availability of hybrid PET/MRI systems, which enables the simultaneous acquisition of both imaging modalities. Furthermore, the advent of ultra-high field MRI scanners operating at magnetic field strengths of 7 T or more will allow further development of metabolic MR imaging at higher resolution. This review focuses on the combination of amino acid PET with MR spectroscopic imaging, perfusion- and diffusion-weighted imaging, as well as chemical exchange saturation transfer in patients with high-grade gliomas, especially glioblastomas.

引用

页数：13

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