Proliferative senescence in hematopoietic stem cells during ex-vivo expansion

被引：0
|
作者：
Piacibello, W [1 ]
Gammaitoni, L [1 ]
Pignochino, Y [1 ]
机构：
[1] Univ Turin, IRCCS Inst Canc Res & Treatment, Lab Med Oncol, Dept Oncol Sci,Med Sch, I-10060 Turin, Italy
来源：
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2005年 / 43卷 / 04期
关键词：
hematopoietic stem cells; cell senescence; telomere shortening; ex vivo expansion; NOD/SCID mice; transplantation;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34(+) cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.
引用
收藏
页码：197 / 202
页数：6
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