Urothelial Carcinoma and Its Metastatic Forms: Medical Treatments Today and Tomorrow

被引：1
作者：
Lavaud, P. [1 ]
Gizzi, M. [1 ]
Loriot, Y. [1 ]
机构：
[1] Gustave Roussy, Grand Paris, Dept Med Oncol, F-94805 Villejuif, France
来源：
ONCOLOGIE | 2015年 / 17卷 / 04期
关键词：
Urothelial carcinoma; Metastatic; Chemotherapy; Targeted therapies; Immunotherapy; TRANSITIONAL-CELL CARCINOMA; PHASE-III TRIAL; HEAT-SHOCK PROTEINS; PROGNOSTIC-FACTORS; CANCER; CISPLATIN; METHOTREXATE; GEMCITABINE; VINBLASTINE; DOXORUBICIN;
D O I：
10.1007/s10269-015-2505-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Urothelial carcinoma remains one of the most common and lethal disease in males. The combination of gemcitabine plus cisplatin with the MVAC regimen is used as first-line chemotherapy for advanced urothelial carcinoma. For unfit patients, the combination of carboplatin and gemcitabine is the preferred option. Currently, there is no standard therapy for patients who failed after first-line platinum-based chemotherapy, although vinflunine has been approved in this setting. However, recent advances in understanding the biological background of urothelial carcinomas have led to new hopes in metastatic disease, mainly with the new immune checkpoint inhibitors (PD-1 and PD-L1 inhibitors). Future strategies targeting the genomic alterations will be assessed in the coming years.
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页码：178 / 183
页数：6
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