Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy

被引：31
|
作者：
Zhu, Huang [1 ]
Lai, Yi-Shin [1 ]
Li, Ye [1 ]
Blum, Robert H. [1 ]
Kaufman, Dan S. [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Regenerat Med, San Diego, CA 92103 USA
来源：
STEM CELLS | 2018年 / 36卷 / 02期
关键词：
Cancer immunotherapy; Adoptive cell therapy; Human pluripotent stem cell; T cell; Natural Killer cell; Natural Killer T cell; NATURAL-KILLER-CELLS; CHIMERIC ANTIGEN RECEPTORS; UMBILICAL-CORD BLOOD; TUMOR-INFILTRATING LYMPHOCYTES; ACUTE MYELOID-LEUKEMIA; T-CELLS; HEMATOPOIETIC STEM; NK CELLS; IN-VIVO; ADOPTIVE TRANSFER;
D O I：
10.1002/stem.2754
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers.
引用
收藏
页码：134 / 145
页数：12
相关论文
共 50 条
  • [21] Cell-based immunotherapy in gynecologic malignancies
    Schaar, Bruce
    Krishnan, Venkatesh
    Tallapragada, Supreeti
    Chanana, Anita
    Dorigo, Oliver
    CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2019, 31 (01) : 43 - 48
  • [22] NK cell-based tumor immunotherapy
    Zhang, Hao
    Yang, Li
    Wang, Tingting
    Li, Zhen
    BIOACTIVE MATERIALS, 2024, 31 : 63 - 86
  • [23] Pluripotent Stem Cell-Based Cancer Therapy: Promise and Challenges
    Sharkis, Saul J.
    Jones, Richard J.
    Civin, Curt
    Jang, Yoon-Young
    SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (127)
  • [24] Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer
    Zhao, Xiaoyan
    Cai, Li
    Hu, Yu
    Wang, Huafang
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [25] Cell-based immunotherapy in gynecologic malignancies
    Kamat, Kalika
    Krishnan, Venkatesh
    Berek, Jonathan S.
    Dorigo, Oliver
    CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2021, 33 (01) : 13 - 18
  • [26] Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells
    Huang, Dehao
    Li, Jianhuan
    Hu, Fangxiao
    Xia, Chengxiang
    Weng, Qitong
    Wang, Tongjie
    Peng, Huan
    Wu, Bingyan
    Wu, Hongling
    Xiong, Jiapin
    Lin, Yunqing
    Wang, Yao
    Zhang, Qi
    Liu, Xiaofei
    Liu, Lijuan
    Zheng, Xiujuan
    Geng, Yang
    Du, Xin
    Zhu, Xiaofan
    Wang, Lei
    Hao, Jie
    Wang, Jinyong
    CELL DISCOVERY, 2022, 8 (01)
  • [27] Engineered human pluripotent stem cell-derived natural killer cells: the next frontier for cancer immunotherapy
    Zhu, Huang
    Kaufman, Dan S.
    BLOOD SCIENCE, 2019, 1 (01): : 4 - 11
  • [28] Novel perspectives on dendritic cell-based immunotherapy of cancer
    Bonaccorsi, Irene
    Pezzino, Gaetana
    Morandi, Barbara
    Ferlazzo, Guido
    IMMUNOLOGY LETTERS, 2013, 155 (1-2) : 6 - 10
  • [29] Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy
    Mashima, Hiroaki
    Zhang, Rong
    Kobayashi, Tsuyoshi
    Tsukamoto, Hirotake
    Liu, Tianyi
    Iwama, Tatsuaki
    Hagiya, Yuichiro
    Yamamoto, Masateru
    Fukushima, Satoshi
    Okada, Seiji
    Idiris, Alimjan
    Kaneko, Shin
    Nakatsura, Tetsuya
    Ohdan, Hideki
    Uemura, Yasushi
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2021, 21 : 171 - 179
  • [30] NK Cell-Based Immunotherapy in Renal Cell Carcinoma
    Terren, Inigo
    Orrantia, Ane
    Mikelez-Alonso, Idoia
    Vitalle, Joana
    Zenarruzabeitia, Olatz
    Borrego, Francisco
    CANCERS, 2020, 12 (02)
12345