Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy

被引：31
|
作者：
Zhu, Huang [1 ]
Lai, Yi-Shin [1 ]
Li, Ye [1 ]
Blum, Robert H. [1 ]
Kaufman, Dan S. [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Regenerat Med, San Diego, CA 92103 USA
来源：
STEM CELLS | 2018年 / 36卷 / 02期
关键词：
Cancer immunotherapy; Adoptive cell therapy; Human pluripotent stem cell; T cell; Natural Killer cell; Natural Killer T cell; NATURAL-KILLER-CELLS; CHIMERIC ANTIGEN RECEPTORS; UMBILICAL-CORD BLOOD; TUMOR-INFILTRATING LYMPHOCYTES; ACUTE MYELOID-LEUKEMIA; T-CELLS; HEMATOPOIETIC STEM; NK CELLS; IN-VIVO; ADOPTIVE TRANSFER;
D O I：
10.1002/stem.2754
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers.
引用
收藏
页码：134 / 145
页数：12
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