Lack of Correlation Between Metallic Elements Analyzed in Hair by ICP-MS and Autism

被引：70
作者：
De Palma, Giuseppe [1 ]
Catalani, Simona [1 ]
Franco, Anna [2 ]
Brighenti, Maurizio [2 ]
Apostoli, Pietro [1 ]
机构：
[1] Univ Brescia, Dept Expt & Appl Med, Sect Occupat Hlth & Ind Hyg, I-25123 Brescia, Italy
[2] Child Neuropsychiat & Dev Ages Psychol Dept, I-37122 Verona, Italy
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 03期
关键词：
Autism; Hair; Metallic elements; Inductively coupled mass spectrometry; MERCURY EXPOSURE; TRACE-ELEMENTS; TOXIC METALS; US CHILDREN; DISORDER; AGE; METHYLMERCURY; BIOMARKERS; MINERALS; SEARCH;
D O I：
10.1007/s10803-011-1245-6
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
A cross-sectional case-control study was carried out to evaluate the concentrations of metallic elements in the hair of 44 children with diagnosis of autism and 61 age-balanced controls. Unadjusted comparisons showed higher concentrations of molybdenum, lithium and selenium in autistic children. Logistic regression analysis confirmed the role of risk factor for male gender and showed a slight association with molybdenum concentrations. Unconventional chelation and vitamin-mineral supplementation were ineffective on elemental hair concentrations. A meta-analysis including the present and previous similar studies excluded any association of autism with hair concentrations of mercury, cadmium, selenium, lithium and copper. A slight association was found for lead only, but it was very weak, as strictly dependent on the worst data from one study.
引用
收藏
页码：342 / 353
页数：12
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