Percutaneous Irreversible Electroporation of Surgically Unresectable Pancreatic Cancer: A Case Report

被引：63
作者：
Bagla, Sandeep [1 ]
Papadouris, Dimitrios [1 ]
机构：
[1] Inova Alexandria Hosp, Cardiovasc & Intervent Radiol Dept, Alexandria, VA 22304 USA
来源：
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2012年 / 23卷 / 01期
关键词：
RADIOFREQUENCY ABLATION; SAFETY;
D O I：
10.1016/j.jvir.2011.10.002
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The present report describes a case of percutaneous irreversible electroporation (IRE) in a 78-year-old man with surgically unresectable stage III (tumor/node/metastasis stages, T4N0M0) pancreatic adenocarcinoma. Two ablations were performed for a 4.1-cm mass encasing the celiac and superior mesenteric artery. At 3 months, a solitary liver metastasis developed, which was treated with radiofrequency ablation followed by gemcitabine chemotherapy. At 6-month follow-up, magnetic resonance imaging demonstrated no residual disease and a decreasing cancer antigen 19-9 level. Percutaneous IRE shows promise as a feasible and potentially safe method for local tumor control in patients with surgically unresectable disease.
引用
收藏
页码：142 / 145
页数：4
相关论文
共 14 条
[1]  
[Anonymous], MED DEV DAT 510K PRE
[2]   Irreversible Electroporation of the Pancreas: Definitive Local Therapy Without Systemic Effects [J].
Bower, Matthew ;
Sherwood, Leslie ;
Li, Yan ;
Martin, Robert .
JOURNAL OF SURGICAL ONCOLOGY, 2011, 104 (01) :22-28
[3]   Irreversible electroporation of the pancreas in swine: a pilot study [J].
Charpentier, Kevin P. ;
Wolf, Farrah ;
Noble, Lelia ;
Winn, Brody ;
Resnick, Murray ;
Dupuy, Damian E. .
HPB, 2010, 12 (05) :348-351
[4]   Radiofrequency ablation of locally advanced pancreatic adenocarcinoma: An overview [J].
D'Onofrio, Mirko ;
Barbi, Emilio ;
Girelli, Roberto ;
Martone, Enrico ;
Gallotti, Anna ;
Salvia, Roberto ;
Martini, Paolo Tinazzi ;
Bassi, Claudio ;
Pederzoli, Paolo ;
Mucelli, Roberto Pozzi .
WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (28) :3478-3483
[5]   Tissue ablation with irreversible electroporation [J].
Davalos, RV ;
Mir, LM ;
Rubinsky, B .
ANNALS OF BIOMEDICAL ENGINEERING, 2005, 33 (02) :223-231
[6]   Feasibility and safety of radiofrequency ablation for locally advanced pancreatic cancer [J].
Girelli, R. ;
Frigerio, I. ;
Salvia, R. ;
Barbi, E. ;
Martini, P. Tinazzi ;
Bassi, C. .
BRITISH JOURNAL OF SURGERY, 2010, 97 (02) :220-225
[7]  
Hadjicostas P, 2006, HPB (Oxford), V8, P61, DOI 10.1080/13651820500466673
[8]   Imaging guided percutaneous irreversible electroporation: Ultrasound and immunohistological correlation [J].
Lee, Edward W. ;
Loh, Christopher T. ;
Kee, Stephen T. .
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2007, 6 (04) :287-293
[9]   Tumour cryoablation combined with palliative bypass surgery in the treatment of unresectable pancreatic cancer: a retrospective study of 142 patients [J].
Li, Jingdong ;
Chen, Xiaoli ;
Yang, Hanfeng ;
Wang, Xiaofei ;
Yuan, Ding ;
Zeng, Yong ;
Wen, Tianfu ;
Yan, Lunan ;
Li, Bo .
POSTGRADUATE MEDICAL JOURNAL, 2011, 87 (1024) :89-95
[10]  
Lygidakis N, 2007, HEPATO-GASTROENTEROL, V54, P1305
12