Platinum (IV)-coordinate polymers as intracellular reduction-responsive backbone-type conjugates for cancer drug delivery

被引：87
作者：
Yang, Jun
Liu, Wenwen
Sui, Meihua [1 ]
Tang, Jianbin
Shen, Youqing
机构：
[1] Zhejiang Univ, Ctr Bionanoengn, Hangzhou 310027, Peoples R China
来源：
BIOMATERIALS | 2011年 / 32卷 / 34期
基金：
美国国家科学基金会; 中国博士后科学基金;
关键词：
Platinum (IV)-conjugate; Platinum (IV) prodrug; Drug delivery; Reduction-responsive; ANTICANCER ACTIVITY; MOLECULAR-WEIGHT; RATIONAL DESIGN; IN-VITRO; CISPLATIN; COMPLEXES; NANOPARTICLES; PRODRUG; MICELLES; SERIES;
D O I：
10.1016/j.biomaterials.2011.08.022
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Platinum (IV)-coordinate polymers were synthesized by condensation polymerization using diamminedichlorodihydroxyplatinum (DHP) or its dicarboxyl derivative diamminedichlorodisuccinatoplatinum (DSP) as comonomers. Cyclic voltammogram study showed that Pt (IV) in the polymers was much easier reduced to Pt (II), particularly at the acidic pH, than that in the monomer DSP. Thus, these polymers were intracellular reduction-responsive backbone-type polymer conjugates that could be degraded and release Pt (II). These conjugates not only had high and fixed platinum contents (27.7% for P(DSP-EDA) and 29.6% for P(DSP-PA), respectively), but also showed increased cytotoxicity compared with corresponding Pt (IV) monomer DSP toward various tumor cell lines. In vivo, the conjugate showed a longer blood circulation time and better tumor accumulation. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9136 / 9143
页数：8
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