Connector sensors for permittivity-based thrombus monitoring in extracorporeal life support

被引：2

作者：

Sifuna, Martin W. ^{[1
]}

Koishi, Madoka ^{[1
]}

Uemura, Takuo ^{[1
]}

Tatekawa, Hanako ^{[2
]}

Haneishi, Hideaki ^{[3
]}

Sapkota, Achyut ^{[4
]}

Takei, Masahiro ^{[1
]}

机构：

[1] Chiba Univ, Div Fundamental Engn, Dept Mech Engn, Grad Sch Sci & Engn,Inage Ku, Chiba, Chiba 2638522, Japan

[2] Chiba Univ, Dept Med Engn, Grad Sch Sci & Engn, Chiba 2638522, Japan

[3] Chiba Univ, Ctr Frontier Med Engn, Chiba 2638522, Japan

[4] Kisarazu Coll, Natl Inst Technol, Dept Informat & Comp Engn, 2-11-1 Kiyomidai Higashi, Kisarazu, Chiba 2920041, Japan

来源：

JOURNAL OF ARTIFICIAL ORGANS | 2021年 / 24卷 / 01期

关键词：

Connector sensor; Connector-tube interface; Extracorporeal circulation; Thrombus monitoring; DIELECTRIC COAGULOMETRY; BLOOD; RESISTANCE; CIRCUIT; MIXTURE;

D O I：

10.1007/s10047-020-01190-z

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Extracorporeal circulation is vital in cardiovascular surgery, but thrombus formation at connector interface is a major threat. Optical coherence tomography (OCT) is presently used to monitor thrombogenesis at connectors, but it is expensive to install and complex to use. This study fabricated and evaluated a connector sensor for real-time permittivity-based thrombus monitoring at tube-connector interface. Computational simulations were initially done to pre-evaluate the applicability of connector sensor. The sensor was fabricated by incorporating two stainless steel electrodes on acrylic tube for measuring permittivity changes at the tube-connector interface. OCT images were also taken from the interface at intervals for comparisons. Results show that the sensor was able to detect thrombus formation at the interface in form of sudden rise in permittivity after timet = 9 min. The permittivity changes were confirmed by OCT images which showed thrombus formation after timet = 14 min implying that permittivity changes were due to regional aggregation of red blood cells. The connector sensor is therefore envisioned as an affordable alternative to OCT for real-time permittivity-based monitoring of thrombogenesis at tube-connector interface.

引用

页码：15 / 21

页数：7