Divergent and Site-Selective Solid-Phase Synthesis of Sulfopeptides

被引：24

作者：

Taleski, Deni ^{[1
]}

Butler, Stephen J. ^{[1
]}

Stone, Martin J. ^{[2
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2011年 / 6卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

chemokine; peptides; receptors; solid-phase synthesis; sulfation; TYROSINE-CONTAINING PEPTIDES; PROTECTING-GROUP STRATEGY; SULFATED-TYROSINE; HIV-1; ENTRY; ENVELOPE GLYCOPROTEIN; AMINO-TERMINUS; N-TERMINUS; PROTEIN; COMPLEX; ANALOG;

D O I：

10.1002/asia.201100232

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On solid ground: A solid-phase strategy for the efficient synthesis of sulfopeptides is described. Selective deprotection of orthogonally-protected tyrosine residues and solid-phase sulfation provided divergent access to differentially sulfated peptides in high yields. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1316 / 1320

页数：5

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