ASPMpredicts poor prognosis and regulates cell proliferation in bladder cancer

被引：18
作者：
Gao, Zhen-Ya [1 ]
Yu, Fang [1 ]
Jia, Huan-Xia [1 ]
Ye, Zhuo [2 ]
Yao, Shi-Jie [3 ]
机构：
[1] Xuchang Univ, Sch Med, Xuchang, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China
[3] Tianjin First Cent Hosp, Dept Urol, Tianjin, Peoples R China
来源：
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES | 2020年 / 36卷 / 12期
关键词：
abnormal spindle-like microcephaly associated; bladder cancer; prognosis; proliferation; ABNORMAL SPINDLE; ASPM GENE; MITOTIC SPINDLE; PROTEIN; ENCODES; EXPRESSION; PATHWAY; MARKER;
D O I：
10.1002/kjm2.12284
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bladder cancer (BCa) is one of the most common malignancies with high morbidity and mortality worldwide. In recent years, it is of great importance to investigate the molecular etiology associated with of BCa. Abnormal spindle-like microcephaly associated gene (ASPM) is the human orthologous of the Drosophila abnormal spindle (asp) and the most commonly mutated gene of autosomal recessive primary microcephaly.ASPMis overexpressed in several types of cancer cell lines and affects the progression and development of multiple types of cancers. However, its possible role in BCa progression is still unclear. Herein, we demonstrated the possible involvement ofASPMin the progression of BCa. We noticed that high expression ofASPMwas positively associated with the poor prognosis. Its knockdown could significantly inhibit the proliferation of BCa cells in vitro and in mice. Therefore, we thoughtASPMcould act as a promising therapeutic target for BCa.
引用
收藏
页码：1021 / 1029
页数：9
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