Deep brain stimulation of the subthalamic nucleus improves sense of well-being in parkinson's disease

被引:16
作者
McDonald, Louise M. [1 ]
Page, Donna [1 ]
Wilkinson, Leonora [1 ,2 ]
Jahanshahi, Marjan [1 ]
机构
[1] UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England
[2] NINDS, Behav Neurol Unit, Bethesda, MD 20892 USA
关键词
Parkinson's disease; deep brain stimulation; subthalamic nucleus; mood; emotion; NONMOTOR FLUCTUATIONS; DOPAMINE; LEVODOPA; APATHY; SURGERY; MOOD;
D O I
10.1002/mds.24035
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed. (c) 2012 Movement Disorder Society
引用
收藏
页码:372 / 378
页数:7
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