Acylphloroglucinol and xanthones from Hypericum ellipticum

被引：14
|
作者：
Manning, Kylie [1 ]
Petrunak, Elyse [1 ]
Lebo, Michelle [1 ]
Gonzalez-Sarrias, Antonio [2 ]
Seeram, Navindra P. [2 ]
Henry, Geneive E. [1 ]
机构：
[1] Susquehanna Univ, Dept Chem, Selinsgrove, PA 17870 USA
[2] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA
来源：
PHYTOCHEMISTRY | 2011年 / 72卷 / 07期
关键词：
Hypericum ellipticum; Clusiaceae; Acylphloroglucinol; Xanthone; Cytotoxicity; BIOSYNTHESIS; DERIVATIVES; CLUSIA;
D O I：
10.1016/j.phytochem.2011.01.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An acylphloroglucinol, elliptophenone A, and two xanthones, elliptoxanthone A and elliptoxanthone B, were isolated from the aerial portions of Hypericum ellipticum together with three known xanthones, 1,3,7-trihydroxy-8-(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,6-dihydroxy-4-methoxy-9H-xanthen-9-one, and 1,4,5-trihydroxy-9H-xanthen-9-one. Their structures were determined by spectroscopic analyses. The acylphloroglucinol and xanthones were evaluated for cytotoxicity using three human colon cancer cell lines cell lines (HT-29, HCT-116 and Caco-2) and a normal human colon cell line (CCD-18Co). (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：662 / 667
页数：6
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