The Fate of Leydig Cells in Men with Spermatogenic Failure

被引：27
作者：
Adamczewska, Daria [1 ]
Slowikowska-Hilczer, Jolanta [1 ]
Walczak-Jedrzejowska, Renata [1 ]
机构：
[1] Med Univ Lodz, Dept Androl & Reprod Endocrinol, PL-92213 Lodz, Poland
来源：
LIFE-BASEL | 2022年 / 12卷 / 04期
关键词：
estradiol; Leydig cells; male infertility; non-obstructive azoospermia; spermatogenic failure; testicular dysgenesis syndrome; testosterone; TESTICULAR DYSGENESIS SYNDROME; INSULIN-LIKE FACTOR-3; IN-UTERO EXPOSURE; HUMAN CHORIONIC-GONADOTROPIN; Y-CHROMOSOME MICRODELETIONS; MALE REPRODUCTIVE DISORDERS; ESTROGEN-RECEPTORS ALPHA; SERTOLI-CELL; ANDROGEN RECEPTOR; MALE-INFERTILITY;
D O I：
10.3390/life12040570
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment, play a vital role in male reproductive tract development, maintenance of proper spermatogenesis, and overall male reproductive function. Therefore, their dysfunction can lead to all sorts of testicular pathologies. Spermatogenesis failure, manifested as azoospermia, is often associated with defective Leydig cell activity. Spermatogenic failure is the most severe form of male infertility, caused by disorders of the testicular parenchyma or testicular hormone imbalance. This review covers current progress in knowledge on Leydig cells origin, structure, and function, and focuses on recent advances in understanding how Leydig cells contribute to the impairment of spermatogenesis.
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页数：29
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