Improving stem cell therapy in cardiovascular diseases: the potential role of microRNA

被引：12
作者：
Nollet, Evelien [1 ,2 ]
Hoymans, Vicky Y. [1 ,2 ]
Van Craenenbroeck, Amaryllis H. [2 ,3 ,4 ]
Vrints, Christiaan J. [1 ,2 ,5 ]
Van Craenenbroeck, Emeline M. [1 ,2 ,5 ]
机构：
[1] Univ Antwerp Hosp, Dept Cardiol, Lab Cellular & Mol Cardiol, Antwerp, Belgium
[2] Univ Antwerp, Dept Translat Pathophysiol Res, Cardiovasc Dis, Antwerp, Belgium
[3] Univ Antwerp Hosp, Dept Nephrol, Antwerp, Belgium
[4] Univ Antwerp, Lab Expt Med & Pediat, Antwerp, Belgium
[5] Univ Antwerp Hosp, Dept Cardiol, Antwerp, Belgium
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2016年 / 311卷 / 01期
关键词：
cardiovascular diseases; microRNA; progenitor cells; stem cell therapy; ENDOTHELIAL PROGENITOR CELLS; CORONARY-ARTERY-DISEASE; NOTCH LIGAND DELTA-LIKE-4; BONE-MARROW; HEART-DISEASE; ISCHEMIC ANGIOGENESIS; MYOCARDIAL-INFARCTION; MONONUCLEAR-CELLS; INDUCED APOPTOSIS; NONCODING RNAS;
D O I：
10.1152/ajpheart.00239.2016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The initial promising prospect of autologous bone marrow-derived stem cell therapy in the setting of cardiovascular diseases has been overshadowed by functional shortcomings of the stem cell product. As powerful epigenetic regulators of (stem) cell function, microRNAs are valuable targets for novel therapeutic strategies. Indeed, modulation of specific miRNA expression could contribute to improved therapeutic efficacy of stem cell therapy. First, this review elaborates on the functional relevance of miRNA dysregulation in bone marrow-derived progenitor cells in different cardiovascular diseases. Next, we provide a comprehensive overview of the current evidence on the effect of specific miRNA modulation in several types of progenitor cells on cardiac and/or vascular regeneration. By elaborating on the cardioprotective regulation of progenitor cells on cardiac miRNAs, more insight in the underlying mechanisms of stem cell therapy is provided. Finally, some considerations are made regarding the potential of circulating miRNAs as regulators of the miRNA signature of progenitor cells in cardiovascular diseases.
引用
收藏
页码：H207 / H218
页数：12
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