Cu-Catalyzed Tandem Oxidation of N-Substituted Indolines to Isatins

被引：2

作者：

Gao, Shanshan ^{[1
]}

Zheng, Junliang ^{[1
]}

Ge, Guoping ^{[1
]}

Luo, Junfei ^{[1
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 46期

关键词：

Cu-catalyzed; N-substituted indolines; Isatin derivatives; Oxidation; tert-Butyl hydroperoxide; ANTICANCER ACTIVITY; GENERAL-METHOD; INDOLES; DESIGN; FUNCTIONALIZATION; DEHYDROGENATION; AROMATIZATION; CONVENIENT; INHIBITORS; ALKALOIDS;

D O I：

10.1002/slct.201803312

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct transformation of N-substituted indoline to isatin derivatives has been developed, this reaction employed cheap Cu catalyst and aqueous tert-butyl hydroperoxide as an oxidant. Primary mechanism studies suggested that the indolines was initially oxidized to indoles which further undergo Cu-catalyzed oxidation to isatins.

引用

页码：13178 / 13181

页数：4

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