Direct N-Me Aziridination of Enones

被引：9

作者：

Jat, Jawahar L. ^{[1
]}

Yadav, Ajay K. ^{[1
]}

Pandey, Chandra Bhan ^{[2
]}

Chandra, Dinesh ^{[1
]}

Tiwari, Bhoopendra ^{[2
]}

机构：

[1] Babasaheb Bhimrao Ambedkar Univ, Dept Chem, Lucknow 226025, Uttar Pradesh, India

[2] Ctr Biomed Res, Dept Biol & Synthet Chem, Lucknow 226014, Uttar Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 05期

关键词：

STEREOSELECTIVE-SYNTHESIS; STEREOSPECIFIC SYNTHESIS; CHALCONES; OLEFINS;

D O I：

10.1021/acs.joc.1c02785

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first direct general method for N-Me aziridination of electron-deficient olefins, enones, is described using N-methyl-O-tosylhydroxylamine as the aminating agent in the presence of a Cu(OTf)(2) catalyst. The aziridination of vinyl ketones, hitherto unknown for N-Me as well as N-H, has been achieved efficiently. The open-flask reaction is stereospecific, operationally simple, and additive-free. It also efficiently affords N-H aziridinated products under a similar reaction condition.

引用

页码：3751 / 3757

页数：7

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