The influence of antibiotic-loaded cement spacers on the risk of reinfection after septic two-stage hip revision surgery

被引：10

作者：

Staats, Kevin ^{[1
]}

Sevelda, Florian ^{[1
]}

Kaider, Alexandra ^{[2
]}

Boehler, Christoph ^{[1
]}

Sigmund, Irene K. ^{[1
]}

Puchner, Stephan E. ^{[1
]}

Windhager, Reinhard ^{[1
]}

Holinka, Johannes ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Orthopaed Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[2] Med Univ Vienna, Sect Clin Biometr, Ctr Med Stat Informat & Intelligent Syst, Waehringer Guertel 18-20, A-1090 Vienna, Austria

来源：

INFECTION | 2017年 / 45卷 / 06期

关键词：

Periprosthetic joint infection; Hip; Spacer; PERIPROSTHETIC JOINT INFECTION; ARTHROPLASTY; REPLACEMENT; SONICATION; INCREASES; DIAGNOSIS; FATE; SITE;

D O I：

10.1007/s15010-017-1081-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was the evaluation of possible outcome differences of patients undergoing two-stage hip exchange with antibiotic-loaded spacers, compared to patients without an interim spacer implantation. We evaluated 46 patients undergoing two-stage hip revision surgery. Twenty-five patients received an interim ALS. Additional to a Kaplan-Meier survival analysis, a competing risk analysis was performed to estimate the cumulative incidence function for re-revisions due to infection accounting for death as a competing event. Nine patients (seven non-ALS vs. two ALS) had to undergo re-revision surgery due to reinfection of the hip joint. The non-ALS group showed a risk of re-revision of 19% (95% CI 5-38%) at 12 and 24 months and 30% (95% CI 12-51%) at 36 months. The group with ALS implantation displayed a 0% risk of re-revision surgery in the first 36 months. The Gray test revealed a significant difference in the cumulative incidence between both observed groups (p = 0.026). Our findings suggest that ALS implantation significantly reduces the risk of reinfection after two-stage hip revision surgery.

引用

页码：885 / 891

页数：7