Synthesis and antibacterial evaluation of novel sulfonamide based [1,2,3]-triazoles

被引：0

作者：

Batra, Neha ^{[1
]}

Roy, Basabi ^{[2
]}

Mazumder, Sibnath ^{[2
]}

Nath, Mahendra ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Univ Delhi, Dept Zool, Delhi 110007, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2015年 / 54卷 / 05期

关键词：

Sulfonamide; 1,2,3]-triazoles; Huisgen [3+2] cycloaddition; alkynes; antibacterial activity; MIT assay; CLICK CHEMISTRY; INHIBITORS; 1,2,3-TRIAZOLE; DERIVATIVES; INFECTIONS; ANTICANCER; TRIAZOLES; DESIGN; AGENTS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of sulfonamide based [1,2,3]-ftiazoles 4a-i, 5 and 6 has been prepared in 65-99% yield through Huisgen [3+2] cycloaddition reaction of 4-azido-N-substitutedbenzenesulfonamides 2a,b with various allcynes (3a-i or phenyl acetylene) in the presence of CuSO4.5H(2)O and sodium ascorbate in t-butanol and water (1:1) mixture at 40 degrees C. The structures of all the newly synthesized molecules have been established on the basis of IR, H-1 and C-13 NMR and high resolution mass spectral analysis. Furthermore, these compounds have been evaluated for their preliminary in vitro antibacterial activity against two Gram-negative bacteria viz. Escherichia coli (MTCC 433) and Salmonella enterica ser. typhi (MTCC 733) and a Gram-positive bacterium viz. Streptococcus mutans (MTCC 497) by using MTT assay.

引用

页码：650 / 655

页数：6

共 43 条

[1] Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues [J].