Molecular regulation of peripheral B cells and their progeny in immunity

被引：45
|
作者：
Boothby, Mark R. [1 ,2 ]
Hodges, Emily [3 ]
Thomas, James W. [1 ,2 ]
机构：
[1] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol Immunol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Med Ctr, Dept Med, Div Rheumatol, Nashville, TN 37232 USA
[3] Vanderbilt Genet Inst, Dept Biochem, Nashville, TN 37232 USA
来源：
GENES & DEVELOPMENT | 2019年 / 33卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
immunity; lymphocytes; signaling; transcription factors; GERMINAL CENTER B; CLASS-SWITCH RECOMBINATION; NF-KAPPA-B; INDUCED CYTIDINE DEAMINASE; T-FOLLICULAR HELPER; ACTIVATION-INDUCED DEAMINASE; TRANSCRIPTION FACTOR FOXO1; RNA-POLYMERASE-II; MEMORY B; PLASMA-CELL;
D O I：
10.1101/gad.320192.118
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naive cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include either terminal differentiation (the long-lived plasma cell) or metastable transcriptional reprogramming (germinal center and memory B cells). In this review, we focus principally on the regulation of differentiation and functional diversification of the "B2" subset. An overview is combined with an account of more recent advances, including initial work on mechanisms that eliminate DNA methylation and potential links between intracellular metabolites and chromatin editing.
引用
收藏
页码：26 / 48
页数：23
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