Predictors of interleukin-33 and thymic stromal lymphopoietin levels in cord blood

被引:9
|
作者
Ashley-Martin, Jillian [1 ]
Dodds, Linda [2 ]
Arbuckle, Tye E. [3 ]
Levy, Adrian R. [4 ]
Platt, Robert W. [5 ]
Marshall, Jean S. [6 ]
机构
[1] Dalhousie Univ, Interdisciplinary PhD Program, Halifax, NS, Canada
[2] Dalhousie Univ, Dept Obstet & Gynaecol & Paediat, Halifax, NS, Canada
[3] Hlth Canada, Hlth Environm & Consumer Safety Branch, Ottawa, ON K1A 0L2, Canada
[4] Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS, Canada
[5] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada
[6] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS, Canada
关键词
allergy; immunoglobulin E; interleukin-33; thymic stromal lymphopoietin; umbilical cord blood; CHILDRENS HEALTH; IMMUNOGLOBULIN-E; RISK-FACTOR; ASTHMA; SYMPTOMS; EXPOSURE; ALLERGY; IMMUNE; IGE;
D O I
10.1111/pai.12340
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
BackgroundThe fetal immune system is a critical window of development. The epithelial cell-derived cytokines, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) have received attention for their role in allergic responses but not been studied during this critical window. The objectives were to assess correlations among IL-33, TSLP, and IgE in umbilical cord blood samples and identify prenatal predictors of these biomarkers. MethodsThis study utilized data and banked cord blood collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analytic sample comprised the 1254 women with a singleton, term birth with a cord blood sample. Spearman correlation coefficients (SCC) and logistic regression models were used to examine associations between biomarkers and identify potential predictors of elevated biomarker levels. ResultsThymic stromal lymphopoietin and IL-33 were more strongly correlated with each other (SCC=0.75, p<0.0001) than with IgE (IL-33 SCC=0.14, TSLP SCC=0.21). Maternal allergy, heavy street traffic, and elevated birth weight were significantly associated with jointly elevated TSLP and IL-33 levels, whereas maternal age and female infant sex were inversely associated with elevated IgE. ConclusionsIn this population of Canadian women and infants, TSLP and IL-33 were detectable in cord blood, more strongly correlated with each other than with IgE, and associated with maternal characteristics indicative of inflammatory responses. This study motivates investigation into the value of cord blood IL-33 and TSLP levels as childhood allergy predictors and raises interesting questions regarding in utero coordinated regulation of these cytokines.
引用
收藏
页码:161 / 167
页数:7
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