Nicotinic Acetylcholine Receptors of PC12 Cells

被引：10

作者：

Mussina, Kamilla ^{[1
]}

Toktarkhanova, Dana ^{[1
]}

Filchakova, Olena ^{[1
]}

机构：

[1] Nazarbayev Univ, Sch Sci & Humanities, Biol Dept, Nursultan, Kazakhstan

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2021年 / 41卷 / 01期

关键词：

nAChRs; PC12; Alpha; 3; beta; 4; 7; 2; 9; NERVE GROWTH-FACTOR; SUBUNIT MESSENGER-RNA; NONNEURONAL CHOLINERGIC SYSTEM; ALPHA-BUNGAROTOXIN RECEPTORS; VENTRAL TEGMENTAL AREA; RAT PHEOCHROMOCYTOMA; CALCIUM PERMEABILITY; INWARD RECTIFICATION; DOPAMINE RELEASE; PHOSPHATIDYLINOSITOL; 3-KINASE;

D O I：

10.1007/s10571-020-00846-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) have gained much attention in the scientific community since they play a significant role in multiple physiological and pathophysiological processes. Multiple approaches to study the receptors exist, with characterization of the receptors' functionality at a single cellular level using cell culturing being one of them. Derived from an adrenal medulla tumor, PC12 cells express nicotinic receptor subunits and form functional nicotinic receptors. Thus, the cells offer a convenient environment to address questions related to the functionality of the receptors. The review summarizes the findings on nicotinic receptors' expression and functions which were conducted using PC12 cells. Specific focus is given to alpha 3-containing receptors as well as alpha 7 receptor. Critical evaluation of findings is provided alongside insights into what can still be learned about nAChRs, using PC12 cells.

引用

页码：17 / 29

页数：13

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