The reaction of procainamide with glucose following admixture to glucose infusion

The kinetics of the reaction of procainamide with glucose to form glucosylamines was investigated over the pH range 1.73-6.00 at 30 degrees C and 5% w/v (0.278 M) glucose concentration. The reaction showed reversible pseudo first-order kinetics with the equilibrium position being controlled by glucose concentration, temperature and pH. Activation parameters for the forward (k(f)) and reverse (k(r)) reactions were 50.1 and 72.2 kJ mol(-1) respectively. The data indicate the rates of both the forward and reverse reactions are markedly influenced by pH giving maximum rates at approximately pH 3.0 and 1.5 respectively. These data confirm that the loss of procainamide would be substantial if admired with glucose infusion. (C) 1998 Elsevier Science B.V. All rights reserved.