Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine

被引：42
|
作者：
Thibault, C [1 ]
L'Heureux, A [1 ]
Bhide, RS [1 ]
Ruel, R [1 ]
机构：
[1] Bristol Myers Squibb Co, Dept Discovery Chem, Pharmaceut Res Inst, Quebec City, PQ J5R 1J1, Canada
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 26期
关键词：
D O I：
10.1021/ol036030z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented, Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange.
引用
收藏
页码：5023 / 5025
页数：3
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