Synthesis of pyranicin and its inhibitory action with bovine heart mitochondrial complex I

被引：24

作者：

Hattori, Yasunao ^{[1
,2
,3
]}

Furuhata, Shin-ichi ^{[2
]}

Okajima, Motonori ^{[2
]}

Konno, Hiroyuki ^{[2
,4
]}

Abe, Masato ^{[2
,5
]}

Miyoshi, Hideto ^{[2
,5
]}

Goto, Tetsuhisa ^{[1
,2
]}

Makabe, Hidefumi ^{[1
,2
]}

机构：

[1] Shinshu Univ, Interdisciplinary Grad Sch Sci & Technol, Nagano 3994598, Japan

[2] Shinshu Univ, Grad Sch Agr, Integrated Dept, Nagano 3994598, Japan

[3] Shinshu Univ, Satellite Venture Business Lab, Nagano 3994598, Japan

[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Chem, Kyoto 602, Japan

[5] Kyoto Univ, Div Appl Life Sci, Grad Sch Agr, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 05期

关键词：

D O I：

10.1021/ol702902w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of pyranicin was achieved using Cl2Pd(CH3CN)(2)-catalyzed diastereoselective cyclization of the allylic ester as the key step. The inhibitory activity of this compound for mitochondrial NADH-ubiquinone oxidoreductase (complex I) was slightly poorer than that of ordinary mono-THF acetogenins such as cis-solamin.

引用

页码：717 / 720

页数：4

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