Carboxylic Acid-Directed Manganese(I)-Catalyzed Regioselective Hydroarylation of Unactivated Alkenes

被引：4

作者：

Han, Jingqiang ^{[1
,2
]}

Yu, Huimin ^{[1
,2
]}

Zi, Weiwei ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elemento Organ Chem, Coll Chem, Tianjin 300071, Peoples R China

[3] Haihe Lab Sustainable Chem Transformat, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 33期

基金：

中国国家自然科学基金;

关键词：

SELECTIVE HYDROARYLATION; PALLADIUM; HYDROCARBOFUNCTIONALIZATION; ANNULATION; ARYLATION;

D O I：

10.1021/acs.orglett.2c02309

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A carboxylic acid-directed regioselective hydroarylation reaction of unactivated alkenes with aryl boronic acids was reported. This transformation was enabled by homogeneous manganese catalyst MnBr(CO)(5) in the presence of KOH and H2O in the m-xylene reaction medium. Both internal and terminal alkenes worked well in this transformation, and a series of functional groups were tolerated. This reaction not only provided an expeditious method to prepare gamma-aryl carboxylic acids from simple starting materials but also would inspire further studies in employing homogeneous manganese catalysis in organic synthesis.

引用

页码：6154 / 6158

页数：5

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