Effects of vertical HIV infection on the persistence of anti-HBs after a schedule of three doses of recombinant hepatitis B vaccine

被引：15

作者：

Fernandes, Sergio Julio ^{[1
]}

Slhessarenko, Natasha ^{[2
]}

Dutra Souto, Francisco Jose ^{[2
]}

机构：

[1] Secretaria Saude Estado Mato Grosso, BR-78020500 Cuiaba, MT, Brazil

[2] Univ Fed Mato Grosso, Fac Ciencias Med, BR-78060900 Cuiaba, MT, Brazil

来源：

VACCINE | 2008年 / 26卷 / 08期

关键词：

perinatal HIV; transmission; hepatitis B vaccine; children;

D O I：

10.1016/j.vaccine.2007.12.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-HBs persistence following HBV vaccination among HIV-positive children has never been systematically studied in central Brazil. An historical cohort study was performed aiming to evaluate persistence of anti-HBs in HIV-positive children in comparison with an HIV-negative child group. Fifty-eight HIV-positive and 116 HIV-negative individuals were enrolled. Birth weight, breast-feeding duration, and the time elapsed since the Last hepatitis B vaccine doses were similar between the groups. Fourteen (24%) out of 58 HIV-positive participants were anti-HBs positive and 101 (87%) out of 116 were HIV-negative (p<0.001). Among anti-HBs-positive individuals, the geometric mean titres were 118 and 298 mlU/mL, respectively to HIV-positive and HIV-negative groups (p=0.04). These results disclose a worrying picture regarding the failure of standard HBV vaccination among Brazilian HIV-infected children. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1032 / 1037

页数：6

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