Assessment of olfactory and gustatory functions in COVID-19 patients

被引:2
作者
Sahin, Muammer Melih [1 ]
Uzunoglu, Eray [1 ]
Yalcin, Mucahit [1 ]
Cesur, Gokcen [1 ]
Yildiz, Mehmet [2 ]
Aysert Yildiz, Pinar [2 ]
Ozger, Hasan Selcuk [2 ]
Cebeci, Suleyman [1 ]
Karamert, Recep [1 ]
Duzlu, Mehmet [1 ]
Tutar, Hakan [1 ]
Dizbay, Murat [2 ]
Ceylan, Alper [1 ]
机构
[1] Gazi Univ, Fac Med, Dept Otorhinolaryngol Head & Neck Surg, Ankara, Turkey
[2] Gazi Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey
关键词
COVID-19; anosmia; ageusia; sniffin sticks; CLINICAL CHARACTERISTICS; DYSFUNCTION;
D O I
10.3906/sag-2102-290
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/aim: This study aims to evaluate of olfactory and gustatory functions of COVID-19 patients and possible risk factors for olfactory and gustatory dysfunctions. Materials and methods: The cross-sectional study included adult patients who were diagnosed with COVID-19 in Gazi University Hospital between April 2020 and June 2020. Volunteered patients participated in a survey in which olfactory and gustatory functions and various clinical information were questioned. Sinonasal Outcome Test-22 was also administrated to all patients. Results: A hundred and seventy-one patients participated in this study. Olfactory and gustatory dysfunctions rates were 10.5% (n: 18) and 10.5% (n: 18), respectively. Patients without any symptom other than smell and taste dysfunctions were clustered as group 1 and patients who are clinically symptomatic were clustered as group 2. Olfactory dysfunction occurred in 8% of group 1 and 17.4% of group 2 (p = 0.072). Gustatory dysfunction rate of smokers was 19.7% and significantly higher than gustatory dysfunction rate of nonsmokers (5.5%) (p = 0.007). Twenty-seven-point-eight percent of the patients with olfactory dysfunction (n = 5) were male and 72.2% (n: 13) were female. Sex did not show significant effect on rate of olfactory dysfunction. Twenty-five patients participated in psychophysical olfactory function test. No participant reported olfactory dysfunction at the time of test. Of the participants, 64% (n: 16) were normosmic and 36% (n: 9) were hyposmic according to Sniffin' Stick test. Conclusion: Olfactory and gustatory dysfunctions are more common in patients who are clinically symptomatic than those diagnosed during contact tracing. Objective tests may show that frequency of olfactory dysfunction is greater than frequency of self-reported olfactory dysfunction.
引用
收藏
页码:2296 / 2303
页数:8
相关论文
共 36 条
[1]   Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis [J].
Agyeman, Akosua Adom ;
Chin, Ken L. ;
Landersdorfer, Cornelia B. ;
Liew, Danny ;
Ofori-Asenso, Richard .
MAYO CLINIC PROCEEDINGS, 2020, 95 (08) :1621-1631
[2]   Prevalence of Anosmia and Ageusia in Patients with COVID-19 at a Primary Health Center, Doha, Qatar [J].
Al-Ani, Raid M. ;
Acharya, Debashis .
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, 2022, 74 (SUPPL 2) :2703-2709
[3]   Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19) [J].
Baig, Abdul Mannan ;
Sanders, Erin C. .
JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) :1845-1857
[4]   Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia [J].
Brann, David H. ;
Tsukahara, Tatsuya ;
Weinreb, Caleb ;
Lipovsek, Marcela ;
Van den Berge, Koen ;
Gong, Boying ;
Chance, Rebecca ;
Macaulay, Iain C. ;
Chou, Hsin-Jung ;
Fletcher, Russell B. ;
Das, Diya ;
Street, Kelly ;
de Bezieux, Hector Roux ;
Choi, Yoon-Gi ;
Risso, Davide ;
Dudoit, Sandrine ;
Purdom, Elizabeth ;
Mill, Jonathan ;
Hachem, Ralph Abi ;
Matsunami, Hiroaki ;
Logan, Darren W. ;
Goldstein, Bradley J. ;
Grubb, Matthew S. ;
Ngai, John ;
Datta, Sandeep Robert .
SCIENCE ADVANCES, 2020, 6 (31)
[5]  
Chen Mengfei, 2020, bioRxiv, DOI [10.1183/13993003.01948-2020, 10.1101/2020.05.08.084996]
[6]   Effect of cigarette smoke on gustatory sensitivity, evaluation of the deficit and of the recovery time-course after smoking cessation [J].
Cheruel, Fabrice ;
Jarlier, Marta ;
Sancho-Garnier, Helene .
TOBACCO INDUCED DISEASES, 2017, 15
[7]   Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sense of Smell [J].
D'Ascanio, Luca ;
Pandolfini, Manlio ;
Cingolani, Cristina ;
Latini, Gino ;
Gradoni, Paolo ;
Capalbo, Maria ;
Frausini, Gabriele ;
Maranzano, Massimo ;
Brenner, Michael J. ;
Di Stadio, Arianna .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2021, 164 (01) :82-86
[8]   Eleven faces of coronavirus disease 2019 [J].
Dong, Xiang ;
Cao, Yi-yuan ;
Lu, Xiao-xia ;
Zhang, Jin-jin ;
Du, Hui ;
Yan, You-qin ;
Akdis, Cezmi A. ;
Gao, Ya-dong .
ALLERGY, 2020, 75 (07) :1699-1709
[9]   Causes of hypogeusia/hyposmia in SARS-CoV2 infected patients [J].
Finsterer, Josef ;
Stollberger, Claudia .
JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) :1793-1794
[10]   Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? [J].
Gane, Simon B. ;
Kelly, Christine ;
Hopkins, Claire .
RHINOLOGY, 2020, 58 (03) :299-301