A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis

被引：1

作者：

Pan, Yang ^{[1
]}

Shi, Weixian ^{[1
]}

Yang, Peng ^{[1
]}

Wu, Shuangsheng ^{[1
]}

Peng, Xiaomin ^{[1
]}

Cui, Shujian ^{[1
]}

Zhang, Daitao ^{[1
]}

Lu, Guilan ^{[1
]}

Zhao, Jiachen ^{[1
]}

Liu, Yimeng ^{[1
]}

Wang, Quanyi ^{[1
]}

机构：

[1] Beijing Ctr Dis Prevent & Control CDC, Inst Infect Dis & Endem Dis Control, Beijing, Peoples R China

来源：

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES | 2015年 / 9卷 / 03期

关键词：

Influenza; H7N9 avian influenza; drug resistance; antibody; viral load; A H7N9 VIRUS; A(H7N9) VIRUS;

D O I：

10.3855/jidc.5875

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study described some essential viral and sera-characteristics of A/H7N9 virus infection in a 61-year old case patient. With the antiviral therapy and respiratory support, the patient showed a significant decrease of viral loads from 6.72 log(10) copies/mL to 0 in 22 days, and a correlated increase of serum hemagglutination inhibition titers during the same period. Phylogenetic analysis demonstrated that the isolated strain was highly homologous to previous strains isolated in the southeast of China. Drug resistance-associated R292K mutation became detectable 17 days after antiviral therapy, but no remarkable influence on the viral clearance was observed.

引用

页码：317 / 320

页数：4

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