Role of Glutathione Peroxidases and Peroxiredoxins in Free Radical-Induced Pathologies

被引：18
作者：
Shaparov, Mars G. [1 ]
Gudkov, Sergey, V [2 ,3 ,4 ]
Lankin, Vadim Z. [5 ]
Novoselov, Vladimir, I [1 ]
机构：
[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Moscow Region, Russia
[2] Russian Acad Sci, Prokhorov Inst Gen Phys, Moscow 119991, Russia
[3] Lobachevsky State Univ Nizhni Novgorod, Inst Biol & Biomed, Nizhnii Novgorod 603022, Russia
[4] All Russian Res Inst Phytopathol, Bolshiye Vyazemy 143050, Russia
[5] Minist Hlth Russia, Natl Med Res Ctr Cardiol, Moscow 121552, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2021年 / 86卷 / 11期
基金：
俄罗斯基础研究基金会;
关键词：
reactive oxygen species; dicarbonyls; peroxiredoxins; glutathione peroxidases; radiation sickness; atherosclerosis; diabetes; LOW-DENSITY LIPOPROTEINS; SUPEROXIDE-DISMUTASE; IONIZING-RADIATION; ANTIOXIDANT ENZYMES; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; CELLS; ATHEROSCLEROSIS; EXPRESSION; MICE;
D O I：
10.1134/S0006297921110067
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we discuss the pathogenesis of some socially significant diseases associated with the development of oxidative stress, such as atherosclerosis, diabetes, and radiation sickness, as well as the possibilities of the therapeutic application of low-molecular-weight natural and synthetic antioxidants for the correction of free radical-induced pathologies. The main focus of this review is the role of two phylogenetically close families of hydroperoxide-reducing antioxidant enzymes peroxiredoxins and glutathione peroxidases - in counteracting oxidative stress. We also present examples of the application of exogenous recombinant antioxidant enzymes as therapeutic agents in the treatment of pathologies associated with free-radical processes and discuss the prospects of the therapeutic use of exogenous antioxidant enzymes, as well as the ways to improve their therapeutic properties.
引用
收藏
页码：1418 / 1433
页数：16
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