Interaction of quercetin glucosides with the intestinal sodium/glucose co-transporter (SGLT-1)

被引：88

作者：

Ader, P ^{[1
]}

Blöck, M ^{[1
]}

Pietzsch, S ^{[1
]}

Wolffram, S ^{[1
]}

机构：

[1] Univ Kiel, Inst Anim Nutr Physiol & Metab, D-24098 Kiel, Germany

来源：

CANCER LETTERS | 2001年 / 162卷 / 02期

关键词：

flavonoids; quercetin; glucoside; absorption; small intestine; sodium/glucose co-transporter-1;

D O I：

10.1016/S0304-3835(00)00645-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently it has been postulated that flavonoid glucosides may be absorbed by the small intestine via the SGLT-1. Therefore, we applied an in vitro mucosal uptake method to investigate mucosal uptake of the non-metabolisable glucose analogue methyl-alpha -D-glucopyranoside (MDG) as influenced by quercetin-3-glucoside (isoquercitrin) and quercetin-4'-glucoside (spiraeosid). We found that both glucosides significantly inhibited SGLT-1 mediated MDG uptake whereas the aglycon quercetin or the quercetin-3-rhamnoglucoside (rutin) were ineffective. Calculated apparent kinetic parameters (K-m, V-max) of initial Na+-dependent MDG uptake by the jejunal mucosa indicate a competitive type of inhibition. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：175 / 180

页数：6

共 25 条

[21] The identification of flavonoids as glycosides in human plasma [J].

Paganga, G ;

RiceEvans, CA .

FEBS LETTERS, 1997, 401 (01) :78-82

[22]

SACHS L, 1992, ANGEWANDTE STAT

[23]

Walgren RA, 2000, J PHARMACOL EXP THER, V294, P830

[24] Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells [J].

Walgren, RA ;

Walle, UK ;

Walle, T .

BIOCHEMICAL PHARMACOLOGY, 1998, 55 (10) :1721-1727

[25]

Walgren RA, 2000, J PHARMACOL EXP THER, V294, P837

← 1 2 3 →