Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint

被引：55

作者：

Silva, P. ^{[1
]}

Barbosa, J. ^{[1
]}

Nascimento, A. V. ^{[1
]}

Faria, J. ^{[1
]}

Reis, R. ^{[1
]}

Bousbaa, H. ^{[1
]}

机构：

[1] CESPU, Inst Super Ciencias Saude Norte, CICS, P-4585116 Gandra Prd, Portugal

来源：

CELL PROLIFERATION | 2011年 / 44卷 / 05期

关键词：

KINETOCHORE-MICROTUBULE INTERACTIONS; SMALL-MOLECULE INHIBITOR; CANCER-CELLS; CYTOPLASMIC DYNEIN; MAD2; ACTIVATION; BI-ORIENTATION; COMPLEX; TENSION; BUBR1; ATTACHMENT;

D O I：

10.1111/j.1365-2184.2011.00767.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.

引用

页码：391 / 400

页数：10

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