Efficient synthesis of 3,4-dihydropyrimidin-2-ones in low melting tartaric acid-urea mixtures

被引：179
作者：
Gore, Sangram [1 ,2 ]
Baskaran, Sundarababu [1 ]
Koenig, Burkhard [2 ]
机构：
[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India
[2] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany
来源：
GREEN CHEMISTRY | 2011年 / 13卷 / 04期
关键词：
ONE-POT SYNTHESIS; ORGANIC-REACTIONS; SALT MIXTURES; CONDENSATION; ALKALOIDS; SOLVENTS; TRIFLATE;
D O I：
10.1039/c1gc00009h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as a novel reaction medium. The melt plays a triple role: as solvent, as catalyst and as reactant, furnishing highly functionalized dihydropyrimidinones in good to excellent yields.
引用
收藏
页码：1009 / 1013
页数：5
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